Drug resistance represents a major obstacle in cancer management, and the mechanisms
underlying stress adaptation of cancer cells in response to therapy-induced hostile …

Mounting evidence indicates that vitamin C has the potential to be a potent anti-cancer
agent when administered intravenously and in high doses (high-dose IVC). Early phase …

With high prevalence and mortality, together with metabolic reprogramming, colorectal
cancer is a leading cause of cancer-related death. Metabolic reprogramming gives tumors …

Metabolic reprogramming that senses brain homeostasis imbalances is necessary to drive
detrimental microglial polarization, and specific targeting of this process contributes to the …

Aerobic glycolysis, or the Warburg effect, is regarded as a critical part of metabolic
reprogramming and plays a crucial role in the occurrence and development of tumours …

Background Osteosarcoma (OS) is the most frequent cancer derived from bone, and the
prognosis of OS is poor. Metabolic alterations have been previously reported to contribute to …

The tumor microenvironment (TME) promotes the malignant transformation of cancer cells,
mainly through metabolic reprogramming. As one of the most prominent features of the TME …

Autophagy, an evolutionarily highly conserved cellular degradation process, plays the Janus
role (either cytoprotective or death-promoting) in colorectal cancer, so the targeting of …

Molecular mechanisms and observational studies have found that diet-derived antioxidants
are associated with digestive system cancers, whereas there is a lack of causal evidence …

Vitamin C, a small organic molecule, is widely found in fruits and vegetables and is an
essential nutrient in the human body. Vitamin C is closely associated with some human …