Sleep-immune interactions are well-known phenomena in everyday life and folk wisdom.
There is no doubt that an infection makes us tired and increases the desire to sleep, and a …

Sleep is an important physiologic process, and lack of sleep is associated with a host of
adverse outcomes. Basic and clinical research has documented the important role circadian …

Delirium is a neurobehavioral syndrome caused by dysregulation of neuronal activity
secondary to systemic disturbances. Over time, a number of theories have been proposed in …

Caspases not only play an essential role during apoptotic cell death, but a subfamily of them—
the inflammatory caspases—are associated with immune responses to microbial pathogens …

It is a common belief that we are more susceptible to infections when deprived of sleep.
Consistent with this, there is increasing evidence that sleep deprivation has detrimental …

Fifteen years have passed since the cloning and characterization of the interleukin-1β-
converting enzyme (ICE/caspase-1), the first identified member of a family of proteases …

Context: Sleep disturbances, pain, and inflammation co-occur in various medical conditions,
but their interrelationships are poorly understood. Objective: We investigated the effects of …

Chronic low‐grade inflammation, in particular increased concentrations of proinflammatory
cytokines such as interleukin (IL)‐6 in the circulation, is observed with increasing age, but it …

Background: Chronic insufficient sleep is a common finding in many pain-related and other
medical diseases and is frequently experienced in the general population. Prolonged …

Delirium is the most common complication found in the general hospital setting. Yet, we
know relatively little about its actual pathophysiology. This article contains a summary of …