Profibrogenic role of IL-15 through IL-15 receptor alpha-mediated trans-presentation in the carbon tetrachloride-induced liver fibrosis model

M Cloutier, B Variya, SA Akbari, F Rexhepi… - Frontiers in …, 2024 - frontiersin.org
Background Inflammatory cytokines play key pathogenic roles in liver fibrosis. IL-15 is a
proinflammatory cytokine produced by myeloid cells. IL-15 promotes pathogenesis of …

IL-15 prolongs anagen, stimulates proliferation, and suppresses apoptosis in the hair matrix of human scalp hair follicles

T Suzuki, F Scala, DL Demetrius… - The Journal of …, 2024 - pubmed.ncbi.nlm.nih.gov
IL-15 Prolongs Anagen, Stimulates Proliferation, and Suppresses Apoptosis in the Hair Matrix of
Human Scalp Hair Follicles IL-15 Prolongs Anagen, Stimulates Proliferation, and Suppresses …

[HTML][HTML] Chemokines and Cytokines in Immunotherapy of Melanoma and Other Tumors: From Biomarkers to Therapeutic Targets

R Reschke, AH Enk, JC Hassel - International Journal of Molecular …, 2024 - mdpi.com
Chemokines and cytokines represent an emerging field of immunotherapy research. They
are responsible for the crosstalk and chemoattraction of immune cells and tumor cells. For …

Signalling mechanisms driving homeostatic and inflammatory effects of interleukin-15 on tissue lymphocytes

N Skariah, OJ James, M Swamy - Discovery Immunology, 2024 - academic.oup.com
There is an intriguing dichotomy in the function of cytokine interleukin-15—at low levels, it is
required for the homeostasis of the immune system, yet when it is upregulated in response …

[PDF][PDF] Quercetin downregulates the expression of IL15 in cancer cells through DNA methylation.

M Zhang, A Lu, H Wang, J Yang - European Review for …, 2023 - europeanreview.org
OBJECTIVE: This study aimed to investigate the effect of quercetin on cellular immunity (via
IL15 expression) against cancer and to elucidate its regulatory mechanism. MATERIALS …

Exploring precision treatments in immune‐mediated inflammatory diseases: Harnessing the infinite potential of nucleic acid delivery

L Xu, Z Shao, X Fang, Z Xin, S Zhao, H Zhang… - …, 2024 - Wiley Online Library
Immune‐mediated inflammatory diseases (IMIDs) impose an immeasurable burden on
individuals and society. While the conventional use of immunosuppressants and disease …

The critical impact of traumatic muscle loss on fracture healing: Basic science and clinical aspects

M Rahmati, M Haffner, MA Lee… - Journal of …, 2024 - Wiley Online Library
Musculoskeletal trauma, specifically fractures, is a leading cause of patient morbidity and
disability worldwide. In approximately 20% of cases with fracture and related traumatic …

[HTML][HTML] The changes of intestinal flora and its relevance with memory Tfh and B cells in rheumatoid arthritis patients treated with csDMARDs and csDMARDs+ …

C Jiang, S Chi, F Wang, C Zhao, X Yang, M Liu, B Ma… - Immunobiology, 2024 - Elsevier
Background A growing body of experimental and clinical evidence has implicated gut
microbiota in the onset and course of rheumatoid arthritis (RA). The imbalance of intestinal …

Interleukin 15 in murine models of colitis

AM Kautzman, JMF Mobulakani… - The Anatomical …, 2023 - Wiley Online Library
Inflammatory bowel diseases (IBDs) are characterized by abnormal, non‐antigen specific
chronic inflammation of unknown etiology. Genome‐wide association studies show that …

miRNA-binding site polymorphism in IL-15RA gene in rheumatoid arthritis and systemic lupus erythematosus: correlation with disease risk and clinical characteristics

N Jadidi, S Alesaeidi, F Arab, B Pakzad, E Siasi… - Clinical …, 2022 - Springer
Introduction/objectives MiRSNPs may interfere with mRNA stability through effects on
microRNAs (miRNAs)-mRNA interactions via direct changes in miRNA binding site or effect …