Tacrolimus is an immunosuppressant with a narrow therapeutic index and pharmacokinetic
variability. This variability may be attributed to genetic variants in gene CYP3A5 associated …

Objective: The aim of this study was to identify the important factors affecting cyclosporine
(CsA) blood concentration and estimate CsA concentration using seven different machine …

Background and objectives Tacrolimus (TAC) has been increasingly used in patients with
non-transplant settings. Because of its large between-subject variability, several population …

We aimed to (i) develop a population pharmacokinetic model of tacrolimus in Chinese lung
transplant recipients and (ii) propose model-based dosing regimens for individualized …

Background and Aim: Tacrolimus (TAC) is a first-line immunosuppressant for the treatment
of refractory nephrotic syndrome (RNS), but the pharmacokinetics of TAC varies widely …

The magnitude of drug-drug interaction between tacrolimus and voriconazole is highly
variable, and individually tailoring the tacrolimus dose when concomitantly administered …

The population pharmacokinetics (PPK) of tacrolimus (TAC) in children with refractory
nephrotic syndrome (RNS) have not been well-characterized. This study aimed to …

Background: There is a substantial lack of tacrolimus pharmacokinetic information in
pediatric hematopoietic stem cell transplant (HSCT) patients. This study aimed to develop …

Objective The purposes of our study were to investigate the population pharmacokinetics of
teicoplanin in Chinese children with different renal functions and to propose the appropriate …

Background and Objective: Tacrolimus, a calcineurin inhibitor widely used as a potent
immunosuppressant to prevent graft rejection, exhibits nonlinear kinetics in patients with …