Extracellular matrices (ECM s) are highly specialized and dynamic three‐dimensional (3D)
scaffolds into which cells reside in tissues. ECM is composed of a variety of fibrillar …

Skeletal disorders are among the leading debilitating factors affecting millions of people
worldwide. The use of stem cells for tissue repair has raised many promises in various …

Osteogenesis imperfecta (OI) is an inherited skeletal dysplasia characterized by bone
fragility and skeletal deformities. While the majority of cases are associated with pathogenic …

The existence of orderly structures, such as tissues and organs is made possible by cell
adhesion, ie, the process by which cells attach to neighbouring cells and a supporting …

Osteogenesis imperfecta is a skeletal dysplasia characterized by bone fragility and
extraskeletal manifestations. Better understanding of the mechanisms of osteogenesis …

In bone, skin, and connective tissues, type I collagen is not only the most abundant collagen,
but it is also essential for tissue integrity. Type I collagen is an interstitial matrix molecule that …

Osteogenesis imperfecta (OI) is a monogenic bone fragility disorder that usually is caused
by mutations in one of the two genes coding for collagen type I alpha chains, COL1A1 or …

The tumor microenvironment is becoming a crucial factor in determining the aggressiveness
of neoplastic cells. The glycosaminoglycan hyaluronan is one of the principal constituents of …

Osteogenesis Imperfecta (OI) is a group of connective tissue disorders with a broad range of
phenotypes characterized primarily by bone fragility. The prevalence of OI ranges from …

Bone mineral density, a bone matrix parameter frequently used to predict fracture risk, is not
the only one to affect bone fragility. Other factors, including the extracellular matrix (ECM) …