Background The demand for clinical trial participants is today one of the highest it has ever
been and continues to increase. At the same time, subject recruitment continues to be …

Depression is common in cancer patients, particularly those with advanced disease. It is
associated with adverse outcomes such as increased pain, disability and poorer prognosis …

Objective Clinical trials have long been considered the 'gold standard'of research generated
evidence in health care. Patient recruitment is an important determinant in the success of the …

Background: Conducting research with dying persons can be controversial and challenging
due to concerns for the vulnerability of the dying and the potential burden on those who …

Background The development of the evidence-base informing end of life (EoL) care is
hampered by the assumption that patients at the EoL are too vulnerable to participate in …

Context Despite international guidelines emphasizing consumer-directed care and
autonomous decisions in research participation, there is a common myth that research can …

Background: Interviews with bereaved family carers to examine the end-of-life experience of
the deceased are important tools for palliative care researchers, but the ethics of …

Purpose: Palliative care is increasingly viewed as a necessary component of cancer care,
especially for patients with advanced disease. Rigorous clinical trials are thus needed to …

There has been a paradigm shift in medicine away from tradition, anecdote and theoretical
reasoning from the basic sciences towards evidence-based medicine (EBM). In palliative …

Cancer is a major cause of global mortality, both in affluent countries and increasingly in
developing nations. Many patients with cancer experience reduced life expectancy and …