Androgens and estrogens in benign prostatic hyperplasia: past, present and future

TM Nicholson, WA Ricke - Differentiation, 2011 - Elsevier
Benign prostatic hyperplasia (BPH) and associated lower urinary tract symptoms (LUTS) are
common clinical problems in urology. While the precise molecular etiology remains unclear …

Estrogen and androgen signaling in the pathogenesis of BPH

CKM Ho, FK Habib - Nature Reviews Urology, 2011 - nature.com
Estrogens and androgens have both been implicated as causes of benign prostatic
hyperplasia (BPH). Although epidemiological data on an association between serum …

Prostate volume in testosterone‐treated and untreated hypogonadal men in comparison to age‐matched normal controls

HM Behre, J Bohmeyer, E Nieschlag - Clinical endocrinology, 1994 - Wiley Online Library
OBJECTIVE The potential use of testosterone preparations for substitution therapy for
ageing men and for male contraception, In addition to the well established substitution …

[HTML][HTML] Androgen receptor roles in the development of benign prostate hyperplasia

K Izumi, A Mizokami, WJ Lin, KP Lai… - The American journal of …, 2013 - Elsevier
Benign prostate hyperplasia (BPH) is a major cause of lower urinary tract symptoms, with an
increased volume of transitional zone and associated with increased stromal cells. It is …

Estrogen receptor–β activated apoptosis in benign hyperplasia and cancer of the prostate is androgen independent and TNFα mediated

SJ McPherson, S Hussain… - Proceedings of the …, 2010 - National Acad Sciences
Prostate cancer (PCa) and benign prostatic hyperplasia (BPH) are androgen-dependent
diseases commonly treated by inhibiting androgen action. However, androgen ablation or …

Benign prostatic hyperplasia—medical and minimally invasive treatment options

JE Oesterling - New England Journal of Medicine, 1995 - Mass Medical Soc
Benign prostatic hyperplasia is a nonmalignant enlargement of the prostate that is due to
excessive cellular growth of both the glandular and the stromal elements of the gland. The …

Hypogonadism and androgen replacement therapy in elderly men

S Basaria, AS Dobs - The American journal of medicine, 2001 - Elsevier
The decrease in testosterone levels with age is both central (pituitary) and peripheral
(testicular) origin. Because serum levels of sex-hormone-binding globulin increase with …

Androgen and pituitary control of penile nitric oxide synthase and erectile function in the rat

DF Penson, C Ng, L Cai, J Rajfer… - Biology of …, 1996 - academic.oup.com
Castration of adult male rats reduces by half the penile erectile response to electrical field
stimulation (EFS) of the cavernosal nerve, and the activity of penile nitric oxide synthase …

[HTML][HTML] Genomic analysis of benign prostatic hyperplasia implicates cellular relandscaping in disease pathogenesis

LW Middleton, Z Shen, S Varma, AS Pollack, X Gong… - JCI insight, 2019 - ncbi.nlm.nih.gov
Benign prostatic hyperplasia (BPH) is the most common cause of lower urinary tract
symptoms in men. Current treatments target prostate physiology rather than BPH …

Effects of alginate oligosaccharide on testosterone-induced benign prostatic hyperplasia in orchiectomized rats

YJ Jang, HY Jung, JY Myeong, KH Song, J Kwon… - Nutrients, 2023 - mdpi.com
Benign prostatic hyperplasia (BPH) is an age-related disease of the urinary system that
affects elderly men. Current treatments for BPH are associated with several adverse effects …