Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that produces a
selective loss of the motor neurons of the spinal cord, brain stem and motor cortex. Oxidative …

Simple Summary Alzheimer's disease (AD) is a progressive disease, where dementia
symptoms gradually worsen. The causes of AD are complex and are characterized by …

Lipid peroxidation products, such as 7-ketocholesterol (7KC), may be increased in the body
fluids and tissues of patients with neurodegenerative diseases and trigger microglial …

BACKGROUND AND PURPOSE: Achieving a specific diagnosis in leukodystrophies is often
difficult due to clinical and genetic heterogeneity. Mitochondrial defects cause 5%–10% of …

Increasing evidence suggests that the peroxisome proliferator-activated receptor γ (PPARγ),
a member of the nuclear receptor superfamily, plays an important role in physiological …

The transcription factor, PPARδ is involved in suppressing inflammation, stimulating
oligodendroglial biogenesis and myelination. Furthermore, activation of PPARδ directly …

Recently, many studies have shown that plant metabolites, such as geraniol (GER), may
exert anti-inflammatory effects in neurodegenerative diseases and, in particular, Parkinson's …

This study focused on the molecular characterization of patients with leukoencephalopathy
associated with a specific biochemical defect of mitochondrial respiratory chain complex III …

Background Dementia risk in women is higher than in men, but the molecular
neuropathology of this gender difference remains poorly defined. In this study, we used …

The maintenance of adequate blood supply and vascular integrity is fundamental to ensure
cerebral function. A wide range of studies report vascular dysfunction in white matter …