X-linked adrenoleukodystrophy (X-ALD) is the most frequent inherited monogenic
demyelinating disease. It is often lethal and currently lacks a satisfactory therapy. The …

Aim: To identify the genetic aetiology of a distinct leukoencephalopathy causing acute
neurological regression in infancy with apparently complete clinical recovery. Methods: We …

Bromethalin toxicosis is an increasingly common clinical presentation in dogs that may be
fatal depending on the extent of intoxication. Antemortem diagnosis of bromethalin toxicosis …

Objective: We investigated whether oxidative phosphorylation (OXPHOS) abnormalities
were associated with lacunar stroke, hypothesizing that these would be more strongly …

www.aging-us.com AGING 2018, Vol. 10, No. 3 Page 1 Sirtuin 2 (SIRT2) is one of seven
members of the NAD+-dependent histone deacetylases (HDAC) family of proteins. Sirtuins …

Ammonia is involved in the pathogenesis of neurological conditions associated with
hyperammonemia, including hepatic encephalopathy. Few is known about the effects of …

Information on the metabolism of tissues in both healthy and diseased states has potential
for detecting tumors, neurodegeneration diseases, diabetes, and many metabolic disorders …

클로르페나피르 (Chlorfenapyr) 는 살충제로서 미토콘드리아의 산화인산화를 방해하여
아데노신삼인산 (adenosine triphosphate) 형성을 억제하고 세포사를 유발하는 것으로 알려져 …

Multiple sclerosis (MS) is a chronic inflammatory demyelinating disorder of the central
nervous system (CNS) and is characterized by a high degree of heterogeneity in …

Background Mitochondrial and neurogenetic diseases can present diagnostic challenges.
We investigated if near infrared spectroscopy with the vascular occlusion test is able to …