Tetracyclines were discovered in the 1940s and exhibited activity against a wide range of
microorganisms including gram-positive and gram-negative bacteria, chlamydiae …

Quinine remains an important anti-malarial drug almost 400 years after its effectiveness was
first documented. However, its continued use is challenged by its poor tolerability, poor …

The emergence and spread of multidrug resistant Plasmodium falciparum has severely
limited the therapeutic options for the treatment of malaria. With ever‐increasing failure rates …

Plasmodium falciparum and Plasmodium vivax, the two protozoan parasite species that
cause the majority of cases of human malaria, have developed resistance to nearly all …

ContextMany US clinicians and laboratory personnel are unfamiliar with the diagnosis and
treatment of malaria. ObjectivesTo examine the evidence base for management of …

Malaria, a parasite vector-borne disease, is one of the greatest health threats in tropical
regions, despite the availability of malaria chemoprophylaxis. The emergence and rapid …

Clinical trials from the 1970s and 1980s have shown the efficacy, safety, and practicability of
the treatment of Plasmodium falciparum malaria with clindamycin. Two reviews from the …

To determine the level of antimalarial drug resistance in southern Papua, Indonesia, we
assessed the therapeutic efficacy of chloroquine plus sulfadoxine–pyrimethamine (CQ+ SP) …

The activities of primaquine in combination with quinine or artesunate against asexual-and
sexual-stage parasites were assessed in 176 adult Thai patients with uncomplicated …

Fosmidomycin acts through inhibition of 1-deoxy-d-xylulose 5-phosphate (DOXP)
reductoisomerase, a key enzyme of the nonmevalonate pathway of isoprenoid biosynthesis …