Alzheimer's disease associated with Down syndrome: a genetic form of dementia
Adults with Down syndrome develop the neuropathological hallmarks of Alzheimer's
disease and are at very high risk of developing early-onset dementia, which is now the …
disease and are at very high risk of developing early-onset dementia, which is now the …
Down syndrome
Trisomy 21, the presence of a supernumerary chromosome 21, results in a collection of
clinical features commonly known as Down syndrome (DS). DS is among the most …
clinical features commonly known as Down syndrome (DS). DS is among the most …
Undulating changes in human plasma proteome profiles across the lifespan
Aging is a predominant risk factor for several chronic diseases that limit healthspan.
Mechanisms of aging are thus increasingly recognized as potential therapeutic targets …
Mechanisms of aging are thus increasingly recognized as potential therapeutic targets …
POSREG: proteomic signature discovered by simultaneously optimizing its reproducibility and generalizability
Mass spectrometry-based proteomic technique has become indispensable in current
exploration of complex and dynamic biological processes. Instrument development has …
exploration of complex and dynamic biological processes. Instrument development has …
Blood and immune development in human fetal bone marrow and Down syndrome
Haematopoiesis in the bone marrow (BM) maintains blood and immune cell production
throughout postnatal life. Haematopoiesis first emerges in human BM at 11–12 weeks after …
throughout postnatal life. Haematopoiesis first emerges in human BM at 11–12 weeks after …
[HTML][HTML] Microbiota-driven tonic interferon signals in lung stromal cells protect from influenza virus infection
KC Bradley, K Finsterbusch, D Schnepf, S Crotta… - Cell reports, 2019 - cell.com
Type I interferon (IFNα/β) pathways are fine-tuned to elicit antiviral protection while
minimizing immunopathology; however, the initiating stimuli, target tissues, and underlying …
minimizing immunopathology; however, the initiating stimuli, target tissues, and underlying …
[HTML][HTML] Non-IgE-mediated gastrointestinal food allergies in children: an update
R Labrosse, F Graham, JC Caubet - Nutrients, 2020 - mdpi.com
Non-immunoglobulin E-mediated gastrointestinal food allergic disorders (non-IgE-GI-FA)
include food protein-induced enterocolitis syndrome (FPIES), food protein-induced …
include food protein-induced enterocolitis syndrome (FPIES), food protein-induced …
[HTML][HTML] Triplication of the interferon receptor locus contributes to hallmarks of Down syndrome in a mouse model
Down syndrome (DS), the genetic condition caused by trisomy 21, is characterized by
variable cognitive impairment, immune dysregulation, dysmorphogenesis and increased …
variable cognitive impairment, immune dysregulation, dysmorphogenesis and increased …
Multidimensional definition of the interferonopathy of Down syndrome and its response to JAK inhibition
Individuals with Down syndrome (DS) display chronic hyperactivation of interferon signaling.
However, the clinical impacts of interferon hyperactivity in DS are ill-defined. Here, we …
However, the clinical impacts of interferon hyperactivity in DS are ill-defined. Here, we …
[HTML][HTML] Individuals with Down syndrome hospitalized with COVID-19 have more severe disease
Purpose Rare genetic conditions like Down syndrome (DS) are historically understudied.
Infection is a leading cause of mortality in DS, along with cardiac anomalies. Currently, it is …
Infection is a leading cause of mortality in DS, along with cardiac anomalies. Currently, it is …