Pathogenesis of ankylosing spondylitis
LS Tam, J Gu, D Yu - Nature Reviews Rheumatology, 2010 - nature.com
Ankylosing spondylitis (AS) is a potentially disabling form of seronegative spondyloarthritis.
The main symptom of AS is inflammatory spinal pain; with time, some patients develop …
The main symptom of AS is inflammatory spinal pain; with time, some patients develop …
The pathogenetic role of HLA-B27 and its subtypes
The strong association between HLA-B27 and ankylosing spondylitis has been known for
more than 33 years, but the enigma of the pathogenetic role of the gene and its product has …
more than 33 years, but the enigma of the pathogenetic role of the gene and its product has …
Genome-wide association and HLA fine-mapping studies identify risk loci and genetic pathways underlying allergic rhinitis
Allergic rhinitis is the most common clinical presentation of allergy, affecting 400 million
people worldwide, with increasing incidence in westernized countries,. To elucidate the …
people worldwide, with increasing incidence in westernized countries,. To elucidate the …
What is the role of HLA-B27 in spondyloarthropathies?
A Chatzikyriakidou, PV Voulgari, AA Drosos - Autoimmunity reviews, 2011 - Elsevier
HLA-B27 (Human Leukocyte Antigen-B27) accounts approximately for the one third of the
overall genetic susceptibility to spondylorthropathies (SpAs). Up to 70 HLA-B27 subtypes …
overall genetic susceptibility to spondylorthropathies (SpAs). Up to 70 HLA-B27 subtypes …
HLA-B27 and the pathogenesis of spondyloarthropathies
JAL de Castro - Immunology letters, 2007 - Elsevier
The association of HLA-B27 with ankylosing spondylitis, a chronic inflammatory disease of
the axial skeleton, and other spondyloarthropathies, is among the strongest of an MHC …
the axial skeleton, and other spondyloarthropathies, is among the strongest of an MHC …
Dynamical characterization of two differentially disease associated MHC class I proteins in complex with viral and self-peptides
D Narzi, CM Becker, MT Fiorillo… - Journal of molecular …, 2012 - Elsevier
Major histocompatibility complex (MHC) class I proteins are expressed on the cell surface
where they present foreign and self-peptides to effector cells of the immune system. While …
where they present foreign and self-peptides to effector cells of the immune system. While …
The role of HLA-B27 in spondyloarthritis
JD Taurog - The Journal of rheumatology, 2010 - jrheum.org
This article summarizes the proceedings of a one-day international workshop held in July
2009 on the role of HLA-B27 in the pathogenesis of ankylosing spondylitis (AS) and related …
2009 on the role of HLA-B27 in the pathogenesis of ankylosing spondylitis (AS) and related …
DockTope: a Web-based tool for automated pMHC-I modelling
M Menegatti Rigo, D Amaral Antunes… - Scientific reports, 2015 - nature.com
The immune system is constantly challenged, being required to protect the organism against
a wide variety of infectious pathogens and, at the same time, to avoid autoimmune disorders …
a wide variety of infectious pathogens and, at the same time, to avoid autoimmune disorders …
Novel HLA-B27-restricted epitopes from Chlamydia trachomatis generated upon endogenous processing of bacterial proteins suggest a role of molecular mimicry in …
C Alvarez-Navarro, JJ Cragnolini… - Journal of Biological …, 2013 - ASBMB
Reactive arthritis (ReA) is an HLA-B27-associated spondyloarthropathy that is triggered by
diverse bacteria, including Chlamydia trachomatis, a frequent intracellular parasite. HLA …
diverse bacteria, including Chlamydia trachomatis, a frequent intracellular parasite. HLA …
Previously hidden dynamics at the TCR–peptide–MHC interface revealed
A structural characterization of the interaction between αβ TCRs and cognate peptide–MHC
(pMHC) is central to understanding adaptive T cell–mediated immunity. X-ray …
(pMHC) is central to understanding adaptive T cell–mediated immunity. X-ray …