Spondyloarthritides: Theories and beyond
B Kocatürk, Z Balık, G Pişiren, U Kalyoncu… - Frontiers in …, 2022 - frontiersin.org
Spondyloarthritides (SpA) are a family of interrelated rheumatic disorders with a typical
disease onset ranging from childhood to middle age. If left untreated, they lead to a severe …
disease onset ranging from childhood to middle age. If left untreated, they lead to a severe …
Citrullination-dependent differential presentation of a self-peptide by HLA-B27 subtypes
A Beltrami, M Rossmann, MT Fiorillo, F Paladini… - Journal of Biological …, 2008 - ASBMB
Inflammatory processes are accompanied by the posttranslational modification of certain
arginine residues within proteins to yield citrulline, although it is largely unknown how this …
arginine residues within proteins to yield citrulline, although it is largely unknown how this …
Implications of structural and thermodynamic studies of HLA-B27 subtypes exhibiting differential association with ankylosing spondylitis
A Ziegler, B Loll, R Misselwitz… - Molecular mechanisms of …, 2009 - Springer
Structural and thermodynamic properties of HLA-B27 molecules provide the basis for their
function within the immune system and are probably also central for the understanding of the …
function within the immune system and are probably also central for the understanding of the …
The rs75862629 minor allele in the endoplasmic reticulum aminopeptidases intergenic region affects human leucocyte antigen B27 expression and protects from …
Objectives HLA-B27 and the endoplasmic reticulum aminopeptidase 1 (ERAP1) and ERAP2
genes are predisposing factors for AS. A single nucleotide polymorphism (SNP) in the …
genes are predisposing factors for AS. A single nucleotide polymorphism (SNP) in the …
Crystallographic structure of a rheumatoid arthritis MHC susceptibility allele, HLA-DR1 (DRB1* 0101), complexed with the immunodominant determinant of human …
EF Rosloniec, RA Ivey, KB Whittington… - The Journal of …, 2006 - journals.aai.org
The expression of HLA-DR1 (DRB1* 0101) is associated with an enhanced risk for
developing rheumatoid arthritis (RA). To study its function, we have solved the three …
developing rheumatoid arthritis (RA). To study its function, we have solved the three …
The role of the unfolded protein response in axial spondyloarthritis
JA Smith - Clinical rheumatology, 2016 - Springer
Susceptibility to ankylosing spondylitis is highly genetic, with a heritability greater than 90%.
Presence of the HLA-B27 MHC class I allele remains the greatest genetic risk factor …
Presence of the HLA-B27 MHC class I allele remains the greatest genetic risk factor …
Individual characterization of stably expanded T cell clones in ankylosing spondylitis patients
IZ Mamedov, OV Britanova, AV Chkalina… - …, 2009 - Taylor & Francis
Ankylosing spondylitis (AS) is commonly characterized by clonal expansions of T cells.
However, these clonal populations are poorly studied and their role in disease initiation and …
However, these clonal populations are poorly studied and their role in disease initiation and …
Different vaccine vectors delivering the same antigen elicit CD8+ T cell responses with distinct clonotype and epitope specificity
M Honda, R Wang, WP Kong, M Kanekiyo… - The Journal of …, 2009 - journals.aai.org
Prime-boost immunization with gene-based vectors has been developed to generate more
effective vaccines for AIDS, malaria, and tuberculosis. Although these vectors elicit potent T …
effective vaccines for AIDS, malaria, and tuberculosis. Although these vectors elicit potent T …
B* 2707 differs in peptide specificity from B* 2705 and B* 2704 as much as from HLA‐B27 subtypes not associated to spondyloarthritis
P Gómez, V Montserrat, M Marcilla… - European journal of …, 2006 - Wiley Online Library
HLA‐B* 2707 is associated with ankylosing spondylitis in most populations. Like the non‐
associated allotypes B* 2706 and B* 2709, it lacks Asp116 and shows preference for …
associated allotypes B* 2706 and B* 2709, it lacks Asp116 and shows preference for …
Functional genomics and its bench-to-bedside translation pertaining to the identified susceptibility alleles and loci in ankylosing spondylitis
Ankylosing spondylitis (AS) is a highly heritable disease for which there is a great unmet
need for improved therapies. Genetics research has identified several major pathways …
need for improved therapies. Genetics research has identified several major pathways …