The Art of War with Pseudomonas aeruginosa: Targeting Mex Efflux Pumps Directly to Strategically Enhance Antipseudomonal Drug Efficacy
Pseudomonas aeruginosa (P. aeruginosa) poses a grave clinical challenge due to its
multidrug resistance (MDR) phenotype, leading to severe and life-threatening infections …
multidrug resistance (MDR) phenotype, leading to severe and life-threatening infections …
What are the missing pieces needed to stop antibiotic resistance?
JL Martínez, F Baquero - Microbial Biotechnology, 2023 - Wiley Online Library
As recognized by several international agencies, antibiotic resistance is nowadays one of
the most relevant problems for human health. While this problem was alleviated with the …
the most relevant problems for human health. While this problem was alleviated with the …
Molecular determinant deciphering of MIC-guided RND efflux substrates in E. coli
J Revol-Tissot, G Boyer, S Alibert - Frontiers in Drug Discovery, 2024 - frontiersin.org
Antimicrobial resistance poses an urgent and formidable global public health threat. The
escalation of bacterial multidrug resistance to antibiotics has the potential to become a …
escalation of bacterial multidrug resistance to antibiotics has the potential to become a …
Role of bacterial multidrug efflux pumps during infection
Multidrug efflux pumps are protein complexes located in the cell envelope that enable
bacteria to expel, not only antibiotics, but also a wide array of molecules relevant for …
bacteria to expel, not only antibiotics, but also a wide array of molecules relevant for …
Unveiling the Druggable Landscape of Bacterial Peptidyl tRNA Hydrolase: Insights into Structure, Function, and Therapeutic Potential
Bacterial peptidyl tRNA hydrolase (Pth) or Pth1 emerges as a pivotal enzyme involved in the
maintenance of cellular homeostasis by catalyzing the release of peptidyl moieties from …
maintenance of cellular homeostasis by catalyzing the release of peptidyl moieties from …
CRISPR/Cas9 介导的adeG 基因敲除大肠杆菌细菌模型的建立
朱恬仪, 孔桂美, 焦红梅, 郭停停, 乌日汗… - 生物技术 …, 2024 - biotech.aiijournal.com
[目的] 鲍曼不动杆菌(Acinetobacter baumannii, AB) 是引起医院内感染的重要条件致病菌之一,
耐药性AB 是目前防治的棘手问题. 细菌外排泵是引起耐药性的重要原因之一, 拟通过PCR …
耐药性AB 是目前防治的棘手问题. 细菌外排泵是引起耐药性的重要原因之一, 拟通过PCR …
Genomic and Proteomic Analysis of Pseudomonas aeruginosa Isolated from Industrial Wastewater to Assess Its Resistance to Antibiotics
Z Wang, W Tian, S Sun, X Chen, H Wang - Separations, 2023 - mdpi.com
Industrial wastewater usually contains a large amount of organic and inorganic pollutants,
and many microorganisms. However, the types of microorganism present in industrial …
and many microorganisms. However, the types of microorganism present in industrial …
Establishment of A Bacterial Model of CRISPR/Cas9 Mediated adeG Gene Knockout in Escherichia coli
T ZHU, G KONG, H JIAO, T GUO, R WU… - Biotechnology …, 2024 - biotech.aiijournal.com
[Objective] Acinetobacter baumannii is one of the important opportunistic pathogens that
cause hospital infections, and the highly resistant A. baumannii is currently a thorny issue in …
cause hospital infections, and the highly resistant A. baumannii is currently a thorny issue in …
[PDF][PDF] Multidrug Efflux Protein Families in Bacteria: ABC, RND, MFS, SMR, MATE, PACE, AbgT (An Update)
Multidrug efflux proteins, also known as efflux pumps, are one of the major mechanisms that
bacteria have evolved for their resistance against antimicrobial agents. Gram-negative …
bacteria have evolved for their resistance against antimicrobial agents. Gram-negative …
[PDF][PDF] Efflux Pumps: Current Targets in the fight against Antibiotic Resistance
M Wilson - Berkeley Scientific Journal, 2023 - escholarship.org
Highly resistant to most antibiotics, intricately-structured Gram-negative bacteria (GNB), such
as E. coli and K. pneumoniae are the cause of some of the world's most rampant infections …
as E. coli and K. pneumoniae are the cause of some of the world's most rampant infections …