Chronic, pathological pain remains a global health problem and a challenge to basic and
clinical sciences. A major obstacle to preventing, treating, or reverting chronic pain has been …

Migraine is a severe neurovascular disorder of which the pathophysiology is not yet fully
understood. Besides the role of inflammatory mediators that interact with the …

The hypothalamic neuropeptide oxytocin (OT) exerts prominent analgesic effects via central
and peripheral action. However, the precise analgesic pathways recruited by OT are largely …

Oxytocin is involved in pain transmission, although the detailed mechanism is not fully
understood. Here, we generate a transgenic rat line that expresses human muscarinic …

The ability to successfully regulate negative emotions such as fear and anxiety is vital for
mental health. Intranasal administration of the neuropeptide oxytocin (OXT) has been shown …

Touch plays a crucial role in affiliative behavior and social communication. The
neuropeptide oxytocin is released in response to touch and may act to facilitate the …

A large body of animal and human laboratory research has linked social interaction and
support to pain perception, with a possible role for the neuropeptide oxytocin as a …

Introduction Oxytocin (OXT) is a peptide hormone produced in the hypothalamus that plays a
neuromodulatory role in emotion, stress, and anxiety. Due to its multidimensional role, OXT …

Background Modulation of pain perception by oxytocin (OXT) has attracted increased
scientific and clinical interest. Neural mechanisms underlying these effects are poorly …

Background Central sensitization is one of the characters of chronic migraine (CM). Aberrant
synaptic plasticity can induce central sensitization. Oxytocin (OT), which is a hypothalamic …