[HTML][HTML] The potential mechanism of postoperative cognitive dysfunction in older people

X Lin, Y Chen, P Zhang, G Chen, Y Zhou, X Yu - Experimental gerontology, 2020 - Elsevier
Postoperative cognitive dysfunction (POCD) is a common disorder following surgery, which
seriously threatens the quality of patients' life, especially the older people. Accumulating …

[HTML][HTML] The role of neuroinflammation in postoperative cognitive dysfunction: moving from hypothesis to treatment

SA Safavynia, PA Goldstein - Frontiers in psychiatry, 2019 - frontiersin.org
Postoperative cognitive dysfunction (POCD) is a common complication of the surgical
experience and is common in the elderly and patients with preexisting neurocognitive …

Post-operative cognitive dysfunction: an exploration of the inflammatory hypothesis and novel therapies

DR Skvarc, M Berk, LK Byrne, OM Dean, S Dodd… - Neuroscience & …, 2018 - Elsevier
Abstract Post-Operative Cognitive Dysfunction (POCD) is a highly prevalent condition with
significant clinical, social and financial impacts for patients and their communities. The …

[HTML][HTML] The Cholinergic System Modulates Memory and Hippocampal Plasticity via Its Interactions with Non-Neuronal Cells

SV Maurer, CL Williams - Frontiers in immunology, 2017 - frontiersin.org
Degeneration of central cholinergic neurons impairs memory, and enhancement of
cholinergic synapses improves cognitive processes. Cholinergic signaling is also anti …

Research progress on the role of inflammatory mechanisms in the development of postoperative cognitive dysfunction

X Tan, LL Qiu, J Sun - BioMed research international, 2021 - Wiley Online Library
Postoperative cognitive dysfunction (POCD), as one of the common postoperative
complications, mainly occurs after surgery and anesthesia, especially in the elderly. It refers …

[HTML][HTML] Effects of prebiotic galacto-oligosaccharide on postoperative cognitive dysfunction and neuroinflammation through targeting of the gut-brain axis

XD Yang, LK Wang, HY Wu, L Jiao - BMC anesthesiology, 2018 - Springer
Background Surgery-induced neuroinflammation plays an important role in postoperative
cognitive dysfunction (POCD). Gut microbiota is a key regulator of neurological …

Lesion of the locus coeruleus damages learning and memory performance in paraquat and maneb-induced mouse Parkinson's disease model

L Hou, F Sun, W Sun, L Zhang, Q Wang - Neuroscience, 2019 - Elsevier
The damage of locus coeruleus (LC) noradrenergic neurons and associated with
norepinephrine (NE) depletion are early events in Parkinson's disease (PD). Previous study …

Prevention of postoperative cognitive dysfunction by minocycline in elderly patients after total knee arthroplasty: a randomized, double-blind, placebo-controlled …

T Takazawa, T Horiuchi, M Orihara, K Nagumo… - …, 2023 - pubs.asahq.org
Background There are no effective pharmacologic interventions for preventing postoperative
cognitive dysfunction in daily practice. Since the antibiotic minocycline is known to suppress …

Systemic inflammation, neuroinflammation and perioperative neurocognitive disorders

S Jia, H Yang, F Huang, W Fan - Inflammation Research, 2023 - Springer
Perioperative neurocognitive disorder (PND) is a common disorder following anesthesia
and surgery, especially in the elderly. The complex cellular and molecular processes are …

Anesthesia, brain changes, and behavior: Insights from neural systems biology

E Colon, EA Bittner, B Kussman, ME McCann… - Progress in …, 2017 - Elsevier
Long-term consequences of anesthetic exposure in humans are not well understood. It is
possible that alterations in brain function occur beyond the initial anesthetic administration …