[HTML][HTML] The potential mechanism of postoperative cognitive dysfunction in older people
X Lin, Y Chen, P Zhang, G Chen, Y Zhou, X Yu - Experimental gerontology, 2020 - Elsevier
Postoperative cognitive dysfunction (POCD) is a common disorder following surgery, which
seriously threatens the quality of patients' life, especially the older people. Accumulating …
seriously threatens the quality of patients' life, especially the older people. Accumulating …
[HTML][HTML] The role of neuroinflammation in postoperative cognitive dysfunction: moving from hypothesis to treatment
SA Safavynia, PA Goldstein - Frontiers in psychiatry, 2019 - frontiersin.org
Postoperative cognitive dysfunction (POCD) is a common complication of the surgical
experience and is common in the elderly and patients with preexisting neurocognitive …
experience and is common in the elderly and patients with preexisting neurocognitive …
Post-operative cognitive dysfunction: an exploration of the inflammatory hypothesis and novel therapies
Abstract Post-Operative Cognitive Dysfunction (POCD) is a highly prevalent condition with
significant clinical, social and financial impacts for patients and their communities. The …
significant clinical, social and financial impacts for patients and their communities. The …
[HTML][HTML] The Cholinergic System Modulates Memory and Hippocampal Plasticity via Its Interactions with Non-Neuronal Cells
SV Maurer, CL Williams - Frontiers in immunology, 2017 - frontiersin.org
Degeneration of central cholinergic neurons impairs memory, and enhancement of
cholinergic synapses improves cognitive processes. Cholinergic signaling is also anti …
cholinergic synapses improves cognitive processes. Cholinergic signaling is also anti …
Research progress on the role of inflammatory mechanisms in the development of postoperative cognitive dysfunction
X Tan, LL Qiu, J Sun - BioMed research international, 2021 - Wiley Online Library
Postoperative cognitive dysfunction (POCD), as one of the common postoperative
complications, mainly occurs after surgery and anesthesia, especially in the elderly. It refers …
complications, mainly occurs after surgery and anesthesia, especially in the elderly. It refers …
[HTML][HTML] Effects of prebiotic galacto-oligosaccharide on postoperative cognitive dysfunction and neuroinflammation through targeting of the gut-brain axis
XD Yang, LK Wang, HY Wu, L Jiao - BMC anesthesiology, 2018 - Springer
Background Surgery-induced neuroinflammation plays an important role in postoperative
cognitive dysfunction (POCD). Gut microbiota is a key regulator of neurological …
cognitive dysfunction (POCD). Gut microbiota is a key regulator of neurological …
Lesion of the locus coeruleus damages learning and memory performance in paraquat and maneb-induced mouse Parkinson's disease model
L Hou, F Sun, W Sun, L Zhang, Q Wang - Neuroscience, 2019 - Elsevier
The damage of locus coeruleus (LC) noradrenergic neurons and associated with
norepinephrine (NE) depletion are early events in Parkinson's disease (PD). Previous study …
norepinephrine (NE) depletion are early events in Parkinson's disease (PD). Previous study …
Prevention of postoperative cognitive dysfunction by minocycline in elderly patients after total knee arthroplasty: a randomized, double-blind, placebo-controlled …
T Takazawa, T Horiuchi, M Orihara, K Nagumo… - …, 2023 - pubs.asahq.org
Background There are no effective pharmacologic interventions for preventing postoperative
cognitive dysfunction in daily practice. Since the antibiotic minocycline is known to suppress …
cognitive dysfunction in daily practice. Since the antibiotic minocycline is known to suppress …
Systemic inflammation, neuroinflammation and perioperative neurocognitive disorders
S Jia, H Yang, F Huang, W Fan - Inflammation Research, 2023 - Springer
Perioperative neurocognitive disorder (PND) is a common disorder following anesthesia
and surgery, especially in the elderly. The complex cellular and molecular processes are …
and surgery, especially in the elderly. The complex cellular and molecular processes are …
Anesthesia, brain changes, and behavior: Insights from neural systems biology
Long-term consequences of anesthetic exposure in humans are not well understood. It is
possible that alterations in brain function occur beyond the initial anesthetic administration …
possible that alterations in brain function occur beyond the initial anesthetic administration …