[99mTc]Tc-PentixaTec: development, extensive pre-clinical evaluation, and first human experience

M Konrad, A Rinscheid, G Wienand, B Nittbaur… - European Journal of …, 2023 - Springer
Purpose The clinical success non-invasive imaging of CXCR4 expression using [68 Ga] Ga-
PentixaFor-PET warrants an expansion of the targeting concept towards conventional …

Diagnostics of atherosclerosis: Overview of the existing methods

AV Poznyak, VN Sukhorukov, II Eremin… - Frontiers in …, 2023 - frontiersin.org
Atherosclerosis was and remains an extremely common and serious health problem. Since
the elderly are most at risk of cardiovascular risk, and the average life expectancy is …

ImmunoPET imaging of hematological malignancies: From preclinical promise to clinical reality

Y Dun, G Huang, J Liu, W Wei - Drug Discovery Today, 2022 - Elsevier
Immuno-positron emission tomography (immunoPET) imaging is a paradigm-shifting
imaging technique for whole-body and all-lesion tumor detection, based on the combined …

Celebrating 80 years anniversary of radioiodine for use in thyroid cancer and perspectives for theranostics

B Hertz, T Watabe, RP Baum - Annals of Nuclear Medicine, 2022 - Springer
In 1942, eighty years ago, Dr. Hertz first conducted radioiodine (RAI) diagnosis and therapy
for thyroid disorders followed later by the successful treatment of thyroid cancer patients …

The role of G protein-coupled receptor kinase 6 regulation in inflammation and pain

M Stegen, UH Frey - International Journal of Molecular Sciences, 2022 - mdpi.com
The G protein-coupled receptor kinase 6 is associated with inflammation and pathological
pain. Impairment of GRK6 expression was described in chronic inflammatory diseases such …

Gallium-68 labelled radiopharmaceuticals for imaging inflammatory disorders

M Vorster - Seminars in Nuclear Medicine, 2023 - Elsevier
Inflammation is an important component of several chronic and debilitating diseases that
result in significant morbidity and mortality. This is best evidenced within the cardiovascular …

PECAM1 combines with CXCR4 to trigger inflammatory cell infiltration and pulpitis progression through activating the NF-κB signaling pathway

Y Liu, Z Zhang, W Li, S Tian - Frontiers in cell and developmental …, 2020 - frontiersin.org
Pulpitis is a frequent bacterially driven inflammation featured with the local accumulation of
inflammatory products in human dental pulps. A GEO dataset GSE16134 comprising data of …

Optimised insert design for improved single-molecule imaging and quantification through CRISPR-Cas9 mediated knock-in

AO Khan, CW White, JA Pike, J Yule, A Slater, SJ Hill… - Scientific reports, 2019 - nature.com
The use of CRISPR-Cas9 genome editing to introduce endogenously expressed tags has
the potential to address a number of the classical limitations of single molecule localisation …

General concepts in theranostics

RF Nunes, RMF Zuppani, AM Coutinho, FG Barbosa… - Pet Clinics, 2021 - pet.theclinics.com
The term “theranostics” was conceived in 2002 1 with the acronym made by the fusion of the
words “therapy” and “diagnostics.” Simplistically, the terminology describes the combined …

Current Status of 68Ga-Pentixafor in Solid Tumours

B Hadebe, MM Sathekge, C Aldous, M Vorster - Diagnostics, 2022 - mdpi.com
Chemokine receptor CXCR4 is overexpressed in neoplasms and its expression is related to
tumour invasion, metastasis and aggressiveness. 68Ga-Pentixafor is used to non-invasively …