68Ga-Pentixafor PET/CT for detection of chemokine receptor CXCR4 expression in myeloproliferative neoplasms

S Kraus, A Dierks, L Rasche, O Kertels… - Journal of Nuclear …, 2022 - Soc Nuclear Med
CXC motif chemokine receptor 4 (CXCR4) is an attractive target for cancer diagnosis and
treatment, as it is overexpressed in many solid and hematologic malignancies. This study …

Sodium butyrate ameliorates non‐alcoholic fatty liver disease by upregulating miR‐150 to suppress CXCR4 expression

N Zhang, Y Qu, B Qin - Clinical and Experimental …, 2021 - Wiley Online Library
Sodium butyrate (NaB) in the gut of animals possesses the potential to modulate lipid
metabolism, regulate innate immunity and protect intestinal health. Accumulating data have …

Melittin: a possible regulator of cancer proliferation in preclinical cell culture and animal models

S Haque, A Hussain, H Joshi, U Sharma… - Journal of Cancer …, 2023 - Springer
Background Melittin is a water-soluble cationic peptide derived from bee venom that has
been thoroughly studied for the cure of different cancers. However, the unwanted …

Impact of the chemokine receptors CXCR4 and CXCR7 on clinical outcome in adrenocortical carcinoma

I Chifu, B Heinze, CT Fuss, K Lang, M Kroiss… - Frontiers in …, 2020 - frontiersin.org
Chemokine receptors have a negative impact on tumor progression in several human
cancers and have therefore been of interest for molecular imaging and targeted therapy …

Preclinical advances in theranostics for the different molecular subtypes of breast cancer

H Fang, A Cavaliere, Z Li, Y Huang… - Frontiers in …, 2021 - frontiersin.org
Breast cancer is the most common cancer in women worldwide. The heterogeneity of breast
cancer and drug resistance to therapies make the diagnosis and treatment difficult …

Radiotheranostic agents in hematological malignancies

J Caers, E Duray, L Vrancken, G Marcion… - Frontiers in …, 2022 - frontiersin.org
Radioimmunotherapy (RIT) is a cancer treatment that combines radiation therapy with tumor-
directed monoclonal antibodies (Abs). Although RIT had been introduced for the treatment of …

Adrenal functional imaging

RA Werner, A Schirbel, AK Buck, M Fassnacht… - La Presse Médicale, 2022 - Elsevier
Given the more widespread use of conventional imaging techniques such as magnetic
resonance imaging or computed tomography, recent years have witnessed an increased …

Diagnostic value of [68Ga] Ga-Pentixafor versus [18F] FDG PET/CTs in non-small cell lung cancer: a head-to-head comparative study

SA Mirshahvalad, R Manafi-Farid… - Nuclear Medicine …, 2023 - journals.lww.com
Objective In this study, we aimed to compare the diagnostic value of [68 Ga] Ga-Pentixafor
and [18 F] FDG PET/CT in the evaluation of non-small cell lung cancer (NSCLC) patients …

Chloroquine inhibits stemness of esophageal squamous cell carcinoma cells through targeting CXCR4-STAT3 pathway

D Yue, D Zhang, X Shi, S Liu, A Li, D Wang… - Frontiers in …, 2020 - frontiersin.org
Esophageal squamous cell carcinoma (ESCC) is one of the most prevalent cancers
worldwide. Recent studies have shown that cancer stem cells (CSCs) are present in ESCC …

The current status and future potential of theranostics to diagnose and treat childhood cancer

AJ Poot, MGEH Lam, MM Van Noesel - Frontiers in oncology, 2020 - frontiersin.org
In theranostics (ie, thera py and diag nostics) radiopharmaceuticals are used for both
therapeutic and diagnostic purposes by targeting one specific tumor receptor. Biologically …