The extracellular signal-regulated kinase (ERK) cascade is a central pathway that transmits
signals from many extracellular agents to regulate cellular processes such as proliferation …

Changes in mRNA stability and translation are critical control points in the regulation of gene
expression, particularly genes encoding growth factors, inflammatory mediators, and proto …

The immunosuppressive protein PD-L1 is upregulated in many cancers and contributes to
evasion of the host immune system. The relative importance of the tumor microenvironment …

Publisher Summary The chapter introduces the mitogen-activated protein (MAP) kinase
(MAPK) module. The identification of MAP kinase pathways exemplifies the power of …

Tristetraprolin (TTP) is a widely expressed potential transcription factor that contains two
unusual CCCH zinc fingers and is encoded by the immediate–early response gene, Zfp-36 …

Mice deficient in tristetraprolin (TTP), the prototype of a family of CCCH zinc finger proteins,
develop an inflammatory syndrome mediated by excess tumor necrosis factor alpha (TNF-α) …

Stress granules (SGs) are dynamic cytoplasmic foci at which stalled translation initiation
complexes accumulate in cells subjected to environmental stress. SG‐associated proteins …

A major function of the mitogen-activated protein kinase (MAPK) pathways is to control
eukaryotic gene expression programmes in response to extracellular signals. MAPKs …

Signal transduction pathways regulate gene expression in part by modulating the stability of
specific mRNAs. For example, the mitogen-activated protein kinase (MAPK) p38 pathway …

Deficiency of tristetraprolin (TTP), the prototype of the CCCH zinc finger proteins, results in a
complex inflammatory syndrome in mice. Most aspects of the syndrome are secondary to …