Towards control of magnetic fluids in patients: directing therapeutic nanoparticles to disease locations

A Nacev, A Komaee, A Sarwar, R Probst… - IEEE Control …, 2012 - ieeexplore.ieee.org
This article describes a range of results, from passive magnet design to optimal feedback
control of a distributed ferrofluid. Representing magnetic forces as the gradient of a magnetic …

[HTML][HTML] Current strategies for drug delivery to the inner ear

H Liu, J Hao, KS Li - Acta Pharmaceutica Sinica B, 2013 - Elsevier
For many years, drug delivery to the inner ear has been a challenge to physicians in the
treatment of inner ear disorders. In the past decade, the field of inner ear drug delivery has …

Chemical screening for hair cell loss and protection in the zebrafish lateral line

AB Coffin, H Ou, KN Owens, F Santos, JA Simon… - Zebrafish, 2010 - liebertpub.com
In humans, most hearing loss results from death of hair cells, the mechanosensory receptors
of the inner ear. Two goals of current hearing research are to protect hair cells from …

Microfabricated reciprocating micropump for intracochlear drug delivery with integrated drug/fluid storage and electronically controlled dosing

V Tandon, WS Kang, TA Robbins, AJ Spencer, ES Kim… - Lab on a Chip, 2016 - pubs.rsc.org
The anatomical and pharmacological inaccessibility of the inner ear is a major challenge in
drug-based treatment of auditory disorders. This also makes pharmacokinetic …

Engineering PLGA nano-based systems through understanding the influence of nanoparticle properties and cell-penetrating peptides for cochlear drug delivery

H Cai, Z Liang, W Huang, L Wen, G Chen - International Journal of …, 2017 - Elsevier
The properties of poly (lactic-co-glycolic acid)(PLGA) nanoparticles (NPs) and penetration
enhancers play a deciding role in the inner ear drug delivery of NPs across the round …

Shaping magnetic fields to direct therapy to ears and eyes

B Shapiro, S Kulkarni, A Nacev, A Sarwar… - Annual review of …, 2014 - annualreviews.org
Magnetic fields have the potential to noninvasively direct and focus therapy to disease
targets. External magnets can apply forces on drug-coated magnetic nanoparticles, or on …

Microsystems technologies for drug delivery to the inner ear

EEL Pararas, DA Borkholder, JT Borenstein - Advanced drug delivery …, 2012 - Elsevier
The inner ear represents one of the most technologically challenging targets for local drug
delivery, but its clinical significance is rapidly increasing. The prevalence of sensorineural …

A nanoliter resolution implantable micropump for murine inner ear drug delivery

F Forouzandeh, X Zhu, A Alfadhel, B Ding… - Journal of controlled …, 2019 - Elsevier
Advances in protective and restorative biotherapies have created new opportunities to use
site-directed, programmable drug delivery systems to treat auditory and vestibular disorders …

Novel multiple agents loaded PLGA nanoparticles for brain delivery via inner ear administration: in vitro and in vivo evaluation

X Zhang, G Chen, L Wen, F Yang, A Shao, X Li… - European Journal of …, 2013 - Elsevier
The aim of this study was to develop novel multiple agents loaded poly (d, l-lactide-co-
glycolide acid)(PLGA) nanoparticles (NPs) and evaluate their potential for brain delivery via …

[HTML][HTML] Preservation of hearing following cochlear implantation using different steroid therapy regimens: a prospective clinical study

MB Skarżyńska, PH Skarżyński, B Król… - … medical journal of …, 2018 - ncbi.nlm.nih.gov
Preservation of Hearing Following Cochlear Implantation Using Different Steroid Therapy
Regimens: A Prospective Clinical Study - PMC Back to Top Skip to main content NIH NLM Logo …