Targeted drug delivery strategies for precision medicines

MT Manzari, Y Shamay, H Kiguchi, N Rosen… - Nature Reviews …, 2021 - nature.com
Progress in the field of precision medicine has changed the landscape of cancer therapy.
Precision medicine is propelled by technologies that enable molecular profiling, genomic …

Organ-on-a-chip: a new paradigm for drug development

C Ma, Y Peng, H Li, W Chen - Trends in pharmacological sciences, 2021 - cell.com
The pharmaceutical industry has been desperately searching for efficient drug discovery
methods. Organ-on-a-Chip, a cutting-edge technology that can emulate the physiological …

[HTML][HTML] Artificial intelligence in cancer target identification and drug discovery

Y You, X Lai, Y Pan, H Zheng, J Vera, S Liu… - … and Targeted Therapy, 2022 - nature.com
Artificial intelligence is an advanced method to identify novel anticancer targets and discover
novel drugs from biology networks because the networks can effectively preserve and …

[HTML][HTML] How much does it cost to research and develop a new drug? A systematic review and assessment

M Schlander, K Hernandez-Villafuerte, CY Cheng… - …, 2021 - Springer
Background Debate over the viability of the current commercial research and development
(R&D) model is ongoing. A controversial theme is the cost of bringing a new molecular entity …

[HTML][HTML] Machine learning methods in drug discovery

L Patel, T Shukla, X Huang, DW Ussery, S Wang - Molecules, 2020 - mdpi.com
The advancements of information technology and related processing techniques have
created a fertile base for progress in many scientific fields and industries. In the fields of drug …

Reactive oxygen species (ROS)-based nanomedicine

B Yang, Y Chen, J Shi - Chemical reviews, 2019 - ACS Publications
Reactive oxygen species (ROS) play an essential role in regulating various physiological
functions of living organisms. The intrinsic biochemical properties of ROS, which underlie …

[HTML][HTML] Supramolecular engineering of hydrogels for drug delivery

S Bernhard, MW Tibbitt - Advanced Drug Delivery Reviews, 2021 - Elsevier
Supramolecular binding motifs are increasingly employed in the design of biomaterials. The
ability to rationally engineer specific yet reversible associations into polymer networks with …

Concepts of artificial intelligence for computer-assisted drug discovery

X Yang, Y Wang, R Byrne, G Schneider… - Chemical …, 2019 - ACS Publications
Artificial intelligence (AI), and, in particular, deep learning as a subcategory of AI, provides
opportunities for the discovery and development of innovative drugs. Various machine …

[HTML][HTML] Applications of PLA in modern medicine

V DeStefano, S Khan, A Tabada - Engineered Regeneration, 2020 - Elsevier
Polylactic acid (PLA) is a versatile biopolymer. PLA is synthesized with ease from abundant
renewable resources and is biodegradable. PLA has shown promise as a biomaterial in a …

[HTML][HTML] The foundation and architecture of precision medicine in neurology and psychiatry

H Hampel, P Gao, J Cummings, N Toschi… - Trends in …, 2023 - cell.com
Neurological and psychiatric diseases have high degrees of genetic and pathophysiological
heterogeneity, irrespective of clinical manifestations. Traditional medical paradigms have …