Atopic dermatitis: pathomechanisms and lessons learned from novel systemic therapeutic options

T Bieber, AS Paller, K Kabashima… - Journal of the …, 2022 - Wiley Online Library
Atopic dermatitis (AD) is a chronic, heterogenous, inflammatory skin disorder associated
with a high skin‐related health burden, typically starting in childhood and often persisting …

[HTML][HTML] Is atopic dermatitis only a skin disease?

A Mesjasz, M Zawadzka, M Chałubiński… - International Journal of …, 2023 - mdpi.com
Atopic dermatitis (AD) is a chronic, pruritic, inflammatory dermatosis that imposes significant
patient and population burdens. In addition to the cutaneous signs and symptoms, growing …

The global burden of atopic dermatitis: lessons from the Global Burden of Disease Study 1990–2017

MR Laughter, MBC Maymone… - British Journal of …, 2021 - academic.oup.com
Summary Background The Global Burden of Disease (GBD) Study provides an annually
updated resource to study disease‐related morbidity and mortality worldwide. Objectives …

[HTML][HTML] Preclinical immunological characterization of rademikibart (CBP-201), a next-generation human monoclonal antibody targeting IL-4Rα, for the treatment of …

L Zhang, Y Ding, Q Wang, W Pan, Z Wei, PA Smith… - Scientific Reports, 2023 - nature.com
Abstract Rademikibart (CBP-201) is a next-generation human monoclonal antibody
targeting IL-4Rα, undergoing evaluation in Phase 2 clinical trials for the treatment of …

[HTML][HTML] The epidemiology of atopic dermatitis in older adults: a population-based study in the United Kingdom

LN Chan, A Magyari, M Ye, NA Al-Alusi, SM Langan… - PloS one, 2021 - journals.plos.org
Background Atopic dermatitis is known to be common among children, but there are few
studies examining the epidemiology across the life course. In particular, there is a paucity of …

Factors associated with depression, anxiety and severe mental illness among adults with atopic eczema or psoriasis: a systematic review and meta-analysis

EI Adesanya, J Matthewman… - British Journal of …, 2023 - academic.oup.com
Background Evidence suggests an association between atopic eczema (AE) or psoriasis
and mental illness; however, the factors associated with mental illness are unclear …

Association of atopic dermatitis and mental health outcomes across childhood: a longitudinal cohort study

C Kern, J Wan, KZ LeWinn, FD Ramirez, Y Lee… - JAMA …, 2021 - jamanetwork.com
Importance Research has highlighted associations between atopic dermatitis (AD) and
mental health conditions in adults. However, literature on the development of mental health …

[HTML][HTML] Common mental health disorders in adults with inflammatory skin conditions: nationwide population-based matched cohort studies in the UK

AD Henderson, E Adesanya, A Mulick, J Matthewman… - BMC medicine, 2023 - Springer
Background Psoriasis and atopic eczema are common inflammatory skin diseases. Existing
research has identified increased risks of common mental disorders (anxiety, depression) in …

Biomarkers associated with the development of comorbidities in patients with atopic dermatitis: a systematic review

C Broderick, S Ziehfreund, K van Bart, B Arents… - Allergy, 2023 - Wiley Online Library
Biomarkers associated with the development of comorbidities in atopic dermatitis (AD)
patients have been reported, but have not yet been systematically reviewed. Seven …

Rademikibart (CBP‐201), a next‐generation monoclonal antibody targeting human IL‐4Rα: Two phase I randomized trials, in healthy individuals and patients with …

J Wang, J White, KJ Sansone… - Clinical and …, 2023 - Wiley Online Library
Abstract IL‐4 and IL‐13 signaling via IL‐4Rα plays key roles in the pathogenesis of atopic
dermatitis (AD) and asthma. Rademikibart (formerly CBP‐201), a next‐generation human …