Advances in biological therapies for dyslipidemias and atherosclerosis

EK Valanti, K Dalakoura-Karagkouni, G Siasos… - Metabolism, 2021 - Elsevier
Atherosclerosis is a multifactorial disease influenced by genetics, lifestyle and
environmental factors. Despite therapeutic advances that reduce the risk of cardiovascular …

HDL in the 21st century: a multifunctional roadmap for future HDL research

A Rohatgi, M Westerterp, A Von Eckardstein… - Circulation, 2021 - Am Heart Assoc
Low high-density lipoprotein cholesterol (HDL-C) characterizes an atherogenic dyslipidemia
that reflects adverse lifestyle choices, impaired metabolism, and increased cardiovascular …

Apolipoprotein mimetic peptides: potential new therapies for cardiovascular diseases

A Wolska, M Reimund, DO Sviridov, MJ Amar… - Cells, 2021 - mdpi.com
Since the seminal breakthrough of treating diabetic patients with insulin in the 1920s, there
has been great interest in developing other proteins and their peptide mimetics as therapies …

[HTML][HTML] Apolipoproteins as potential communicators play an essential role in the pathogenesis and treatment of early atherosclerosis

Y Li, X Luo, Z Hua, X Xue, X Wang, M Pang… - … Journal of Biological …, 2023 - ncbi.nlm.nih.gov
Atherosclerosis as the leading cause of the cardiovascular disease is closely related to
cholesterol deposition within subendothelial areas of the arteries. Significantly, early …

Reconstituted HDL-apoE3 promotes endothelial cell migration through ID1 and its downstream kinases ERK1/2, AKT and p38 MAPK

EK Valanti, K Dalakoura-Karagkouni, P Fotakis… - Metabolism, 2022 - Elsevier
Abstract Introduction Atherosclerotic Coronary Artery Disease (ASCAD) is the leading cause
of mortality worldwide. Novel therapeutic approaches aiming to improve the atheroprotective …

Apolipoprotein and LRP1-based peptides as new therapeutic tools in atherosclerosis

A Benitez Amaro, A Solanelles Curco, E Garcia… - Journal of clinical …, 2021 - mdpi.com
Apolipoprotein (Apo)-based mimetic peptides have been shown to reduce atherosclerosis.
Most of the ApoC-II and ApoE mimetics exert anti-atherosclerotic effects by improving lipid …

[HTML][HTML] Hepatic paraoxonase 1 ameliorates dysfunctional high-density lipoprotein and atherosclerosis in scavenger receptor class B type I deficient mice

XJ Zhao, LC Liu, C Guo, WW Shen, J Cao… - Annals of …, 2021 - ncbi.nlm.nih.gov
Background: High-density lipoprotein (HDL) plays an antiatherogenic role by mediating
reverse cholesterol transport (RCT), antioxidation, anti-inflammation, and endothelial cell …

Apolipoprotein A-IV and its derived peptide, T55− 121, improve glycemic control and increase energy expenditure

Z Cao, L Lei, Z Zhou, S Xu, L Wang, W Gong… - Life …, 2024 - academic.oup.com
It is crucial to understand the glucose control within our bodies. Bariatric/metabolic
surgeries, including laparoscopic sleeve gastrectomy (LSG) and Roux-en-Y gastric bypass …

Simultaneous quantification of apolipoproteins AI, E, and J in human plasma by LC-MS/MS for clinical application to diabetes mellitus complicated with cardiovascular …

P Li, Y Cong, W Zhang, L Wang, L Ren, X Li, S Yang… - RSC …, 2022 - pubs.rsc.org
Apolipoproteins (Apos) play an important role in regulating plasma lipid concentration.
Complex disorders of Apos are highly related with diabetes mellitus, cardiovascular and …

Global research trends of Apolipoprotein E in central nervous system: A scientometric analysis

K Gong, Y Chen, W Liu, Z Wang - International Immunopharmacology, 2021 - Elsevier
Abstract Apolipoprotein E (apoE, protein; APOE, gene) involves in cholesterol recycling and
redistribution by mediating lipoprotein pathways unique to central nervous system (CNS) …