[HTML][HTML] Mechanistic concepts of iron-sulfur protein biogenesis in Biology
JJ Braymer, SA Freibert, M Rakwalska-Bange… - Biochimica et Biophysica …, 2021 - Elsevier
Abstract Iron-sulfur (Fe/S) proteins are present in virtually all living organisms and are
involved in numerous cellular processes such as respiration, photosynthesis, metabolic …
involved in numerous cellular processes such as respiration, photosynthesis, metabolic …
Biogenesis of iron–sulfur clusters and their role in DNA metabolism
R Shi, W Hou, ZQ Wang, X Xu - Frontiers in Cell and Developmental …, 2021 - frontiersin.org
Iron–sulfur (Fe/S) clusters (ISCs) are redox-active protein cofactors that their synthesis,
transfer, and insertion into target proteins require many components. Mitochondrial ISC …
transfer, and insertion into target proteins require many components. Mitochondrial ISC …
Genome-wide synthetic lethal screen unveils novel CAIX-NFS1/xCT axis as a targetable vulnerability in hypoxic solid tumors
The metabolic mechanisms involved in the survival of tumor cells within the hypoxic niche
remain unclear. We carried out a synthetic lethal CRISPR screen to identify survival …
remain unclear. We carried out a synthetic lethal CRISPR screen to identify survival …
Mitochondrial [4Fe-4S] protein assembly involves reductive [2Fe-2S] cluster fusion on ISCA1–ISCA2 by electron flow from ferredoxin FDX2
BD Weiler, MC Brück, I Kothe, E Bill… - Proceedings of the …, 2020 - National Acad Sciences
The essential process of iron-sulfur (Fe/S) cluster assembly (ISC) in mitochondria occurs in
three major phases. First,[2Fe-2S] clusters are synthesized on the scaffold protein ISCU2; …
three major phases. First,[2Fe-2S] clusters are synthesized on the scaffold protein ISCU2; …
A VDAC1-mediated NEET protein chain transfers [2Fe-2S] clusters between the mitochondria and the cytosol and impacts mitochondrial dynamics
Mitochondrial inner NEET (MiNT) and the outer mitochondrial membrane (OMM) mitoNEET
(mNT) proteins belong to the NEET protein family. This family plays a key role in …
(mNT) proteins belong to the NEET protein family. This family plays a key role in …
[HTML][HTML] METTL17 is an Fe-S cluster checkpoint for mitochondrial translation
Friedreich's ataxia (FA) is a debilitating, multisystemic disease caused by the depletion of
frataxin (FXN), a mitochondrial iron-sulfur (Fe-S) cluster biogenesis factor. To understand the …
frataxin (FXN), a mitochondrial iron-sulfur (Fe-S) cluster biogenesis factor. To understand the …
Mechanisms of cellular iron sensing, regulation of erythropoiesis and mitochondrial iron utilization
To maintain an adequate iron supply for hemoglobin synthesis and essential metabolic
functions while counteracting iron toxicity, humans and other vertebrates have evolved …
functions while counteracting iron toxicity, humans and other vertebrates have evolved …
From the discovery to molecular understanding of cellular iron-sulfur protein biogenesis
R Lill - Biological chemistry, 2020 - degruyter.com
Protein cofactors often are the business ends of proteins, and are either synthesized inside
cells or are taken up from the nutrition. A cofactor that strictly needs to be synthesized by …
cells or are taken up from the nutrition. A cofactor that strictly needs to be synthesized by …
[HTML][HTML] CIAO1 loss of function causes a neuromuscular disorder with compromise of nucleocytoplasmic Fe-S enzymes
Cytoplasmic and nuclear iron-sulfur (Fe-S) enzymes that are essential for genome
maintenance and replication depend on the cytoplasmic Fe-S assembly (CIA) machinery for …
maintenance and replication depend on the cytoplasmic Fe-S assembly (CIA) machinery for …
High levels of frataxin overexpression lead to mitochondrial and cardiac toxicity in mouse models
B Belbellaa, L Reutenauer, N Messaddeq… - … Therapy-Methods & …, 2020 - cell.com
Friedreich ataxia (FA) is currently an incurable inherited mitochondrial disease caused by
reduced levels of frataxin (FXN). Cardiac dysfunction is the main cause of premature death …
reduced levels of frataxin (FXN). Cardiac dysfunction is the main cause of premature death …