Schwann cells are glial cells of the peripheral nervous system. They exist in several
subtypes and perform a variety of functions in nerves. Their derivation and culture in vitro are …

A growing body of studies indicate that small noncoding RNAs, especially microRNAs
(miRNA), play a crucial role in response to peripheral nerve injuries. During Wallerian …

Peripheral nerve injuries arising from trauma or disease can lead to sensory and motor
deficits and neuropathic pain. Despite the purported ability of the peripheral nerve to self …

Schwann cells (SCs) are a highly plastic cell type capable of undergoing phenotypic
changes following injury or disease. SCs are able to upregulate genes associated with …

Background Plenty of macrophages are recruited to the injured nerve to play key roles in the
immunoreaction and engulf the debris of degenerated axons and myelin during Wallerian …

Our previous studies indicated that RhoA knockdown or inhibition could alleviate the
proliferation, migration, and differentiation of Schwann cells. However, the role of RhoA in …

Abstract Alzheimer's disease (AD), a chronic, progressive, neurodegenerative disorder, is
the most common type of dementia. Beta amyloid (Aβ) peptide aggregation and …

Wallerian degeneration, the progressive disintegration of distal axons and myelin that
occurs after peripheral nerve injury, is essential for creating a permissive microenvironment …

Abstract Pannexin 1 (Panx 1), as a large-pore membrane channel, is highly permeable to
ATP and other signaling molecules. Previous studies have demonstrated the expression of …

Glucagon-like peptide-1 receptor agonists (GLP-1RAs) were developed as insulinotropic
and anti-hyperglycemic agents for the treatment of type 2 diabetes, but their neurotrophic …