Low-dose MTX administered weekly remains a mainstay in the therapy of RA. There is a
belief amongst rheumatologists that RA patients taking MTX have both an increased risk and …

Recent evidence implicates an adaptive immune response in the central nervous system
(CNS) mechanisms of neuropathic pain. This review identifies how neuropathic pain alters …

Methotrexate is a cytostatic drug applied in adjuvant chemotherapy and associated with
cognitive impairment in part of the cancer patients. In this paper we studied in rats whether a …

Background The therapy of cutaneous lupus erythematosus (CLE) is often challenging,
especially in patients resistant to topical treatment and established first‐line systemic drugs …

Vascular endothelial growth factor‐A (VEGF‐A), the main angiogenic mediator, plays a
critical role in the pathogenesis of several inflammatory immune‐mediated diseases …

Abstract Some derivatives containing pyrido [2, 3-d: 6, 5d′] dipyrimidine-4, 5-diones (9a-f),
tetrahydropyrido [2, 3-d] pyrimidine-6-carbonitriles (11a-c) and 6-(4-acetylphenyl)-2-thioxo …

Background Inflammatory arthritis (IA), including rheumatoid arthritis (RA), ankylosing
spondylitis (AS) and psoriatic arthritis (PsA), leads to increased cardiovascular disease …

The wide distribution of ATP and adenosine receptors as well as enzymes for purine
metabolism in different gut regions suggests a complex role for these mediators in the …

Inflammation contributes to all phases of the atherothrombotic process, patients with
elevated inflammatory biomarkers such as high-sensitivity C-reactive protein (hsCRP) have …

Background Reports of methotrexate for chronic urticaria are anecdotal. Objectives To
assess the effectiveness of methotrexate in steroid‐dependent chronic urticaria, its impact …