[HTML][HTML] An update on human T-cell leukemia virus type I (HTLV-1)-associated myelopathy/tropical spastic paraparesis (HAM/TSP) focusing on clinical and laboratory …

J Yamauchi, N Araya, N Yagishita, T Sato… - Pharmacology & …, 2021 - Elsevier
Human T-cell leukemia virus type I (HTLV-1)-associated myelopathy/tropical spastic
paraparesis (HAM/TSP) is a rare inflammatory disease causing unremitting and progressive …

[HTML][HTML] Pathogenesis of HTLV-1 infection and progression biomarkers: An overview

C Brites, MF Grassi, JAS Quaresma, R Ishak… - Brazilian Journal of …, 2021 - SciELO Brasil
Infection by human T-cell lymphotropic virus type 1 (HTLV-1) occurs in lymphocytes, which
travel throughout the body, thus affecting several target organs and causing varied clinical …

Efficacy of corticosteroid therapy for HTLV-1-associated myelopathy: a randomized controlled trial (HAMLET-P)

J Yamauchi, K Tanabe, T Sato, M Nakagawa… - Viruses, 2022 - mdpi.com
Corticosteroids are most commonly used to treat HTLV-1-associated myelopathy (HAM);
however, their clinical efficacy has not been tested in randomized clinical trials. This …

The Role of Chemokines in the Pathogenesis of HTLV-1

R Zargari, M Mahdifar, A Mohammadi… - Frontiers in …, 2020 - frontiersin.org
Human T cell leukemia virus type 1 (HTLV-1) is a human retrovirus that is associated with
two main diseases: HTLV-associated myelopathy/tropical spastic paraparesis (HAM/TSP) …

Following the clues: usefulness of biomarkers of neuroinflammation and neurodegeneration in the investigation of HTLV-1-associated myelopathy progression

FS Souza, NL Freitas, YCP Gomes, RC Torres… - Frontiers in …, 2021 - frontiersin.org
Human T-lymphotropic virus type 1 (HTLV-1)-associated myelopathy/tropical spastic
paraparesis (HAM/TSP) is a neurodegenerative disease due to axonal damage of the …

TNF-induced metalloproteinase-9 production is associated with neurological manifestations in HTLV-1-infected individuals

M Guerra, NB Carvalho, S Santos… - Frontiers in …, 2022 - frontiersin.org
HTLV-1-infected individuals may develop a neurologic inflammatory condition known as
HTLV-1-associated myelopathy (HAM/TSP), in which the high production of TNF is …

[HTML][HTML] Biomarkers for prognosis of neuroinflammation and neurodegeneration associated with acute and chronic viral diseases

OM Espíndola, J Echevarria-Lima… - Frontiers in …, 2024 - frontiersin.org
Many RNA and DNA viruses exhibit neuroinvasive properties and can be associated with
acute or chronic neurological manifestations (Debiasi and Tyler, 2004). Therefore, rapid …

Establishment of a cynomolgus macaque model of human T-cell leukemia virus type 1 (HTLV-1) infection by direct inoculation of adult T-cell leukemia patient-derived …

E Urano, K Ueda, M Higuchi, M Furukawa… - Journal of …, 2022 - Am Soc Microbiol
HTLV-1 was discovered in the 1980s as the causative agent of adult T-cell leukemia and
HTLV-1-associated myelopathy/tropical spastic paraparesis. However, the precise …

Multicenter, randomized, double-blind, placebo-controlled phase 3 study of mogamulizumab with open-label extension study in a minimum number of patients with …

T Sato, M Nagai, O Watanabe, T Misu… - Journal of …, 2024 - Springer
Human T-cell leukemia virus type 1 (HTLV-1)-associated myelopathy/tropical spastic
paraparesis (HAM/TSP) is a chronic neurodegenerative disease characterized by …

Potential role of HTLV-1 Tax-specific cytotoxic t lymphocytes expressing a unique t-cell receptor to promote inflammation of the central nervous system in myelopathy …

Y Tanaka, T Sato, N Yagishita, J Yamauchi… - Frontiers in …, 2022 - frontiersin.org
Human T-lymphotropic virus 1 (HTLV-1) infection causes two serious diseases: adult T-cell
leukemia/lymphoma (ATL) and HTLV-1-associated myelopathy (HAM). Immunological …