Control of host mitochondria by bacterial pathogens

S Marchi, G Morroni, P Pinton, L Galluzzi - Trends in Microbiology, 2022 - cell.com
Mitochondria control various processes that are integral to cellular and organismal
homeostasis, including Ca 2+ fluxes, bioenergetic metabolism, and cell death. Perhaps not …

[HTML][HTML] Pgp3 protein of Chlamydia trachomatis inhibits apoptosis via HO-1 upregulation mediated by PI3K/Akt activation

M Shu, J Bu, W Lei, L Chen, Z Zhou, C Lu, C Chen… - Microbial …, 2023 - Elsevier
As an obligate intracellular pathogen, Chlamydia trachomatis assumes various strategies to
inhibit host cells apoptosis, thereby providing a suitable intracellular environment to ensure …

Chlamydia Infection Remodels Host Cell Mitochondria to Alter Energy Metabolism and Subvert Apoptosis

HC Cheong, S Sulaiman, CY Looi, LY Chang… - Microorganisms, 2023 - mdpi.com
Chlamydia infection represents an important cause for concern for public health worldwide.
Chlamydial infection of the genital tract in females is mostly asymptomatic at the early stage …

Chlamydia trachomatis Pgp3 protein regulates oxidative stress via activation of the Nrf2/NQO1 signal pathway

M Shu, W Lei, S Su, Y Wen, F Luo, L Zhao, L Chen… - Life Sciences, 2021 - Elsevier
Aim Chlamydia trachomatis has evolved various strategies to alleviate oxidative stress of
host cells to maintain their intracellular survival. However, the exact mechanism of anti …

Chlamydia trachomatis Plasmid Protein pORF5 Up-Regulates ZFAS1 to Promote Host Cell Survival via MAPK/p38 Pathway

Y Wen, H Chen, F Luo, L Zhao, M Shu, S Su… - Frontiers in …, 2020 - frontiersin.org
Long non-coding RNAs (lncRNAs) have been demonstrated to play essential roles in many
diseases. However, few studies have shown that lncRNAs take part in the pathogenesis of …

Antiapoptotic activity of Chlamydia trachomatis Pgp3 protein involves activation of the ERK1/2 pathway mediated by upregulation of DJ-1 protein

F Luo, M Shu, S Gong, Y Wen, B He… - Pathogens and …, 2019 - academic.oup.com
Chlamydia trachomatis has evolved strategies to prevent host cell apoptosis to evade the
host immune defense. However, the precise mechanisms of antiapoptotic activity of C …

Chlamydia trachomatis induces lncRNA MIAT upregulation to regulate mitochondria‐mediated host cell apoptosis and chlamydial development

F Luo, Y Wen, L Zhao, S Su, Y Zhao… - Journal of cellular and …, 2022 - Wiley Online Library
Chlamydia trachomatis persistent infection is the leading cause of male prostatitis and
female genital tract diseases. Inhibition of host cell apoptosis is the key to maintaining …

Chlamydia trachomatis plasmid-encoded protein pORF5 activates unfolded protein response to induce autophagy via MAPK/ERK signaling pathway

Y Wen, F Luo, Y Zhao, S Su, M Shu, Z Li - Biochemical and biophysical …, 2020 - Elsevier
Chlamydia trachomatis (C. trachomatis) is an obligate intracellular organism that depends
on nutrients from the host cell for their replication and proliferation. Therefore, the interaction …

Bacteria exploit autophagy for their own benefit

Q Xiong, M Yang, P Li, C Wu - Infection and Drug Resistance, 2019 - Taylor & Francis
Autophagy is a lysosomal degradation pathway to clear long-lived proteins, protein
aggregates, and damaged organelles. Certain microorganisms can be eliminated by an …

TLR2 mediates autophagy through ERK signaling pathway in Chlamydia psittaci CPSIT_p7 protein‐stimulated RAW264.7 cells

Y Luo, Z Sun, Q Chen, J Xiao, XL Yan… - Microbiology and …, 2023 - Wiley Online Library
Chlamydia psittaci is a zoonotic pathogen found in birds and humans. Macrophages, major
components of the innate immune system, can resist chlamydial infections and trigger …