Dynein-decorated doublet microtubules (DMTs) are critical components of the oscillatory
molecular machine of cilia, the axoneme, and have luminal surfaces patterned periodically …

In 2019, the Nosology Committee of the International Skeletal Dysplasia Society provided an
updated version of the Nosology and Classification of Genetic Skeletal Disorders. This is a …

The structural and functional similarity of the larval zebrafish pronephros to the human
nephron, together with the recent development of easier and more precise techniques to …

Ovarian endometriosis is characterized by the growth of endometrial tissue within the ovary,
causing infertility and chronic pain. However, its pathophysiology remains unclear. Utilizing …

Motile and non-motile cilia are associated with mutually-exclusive genetic disorders. Motile
cilia propel sperm or extracellular fluids, and their dysfunction causes primary ciliary …

How does SARS-CoV-2 cause lung microenvironment disturbance and inflammatory storm
is still obscure. We here performed the single-cell transcriptome sequencing from lung …

Mutations in TUB-like protein 1 (TULP1) are associated with severe early-onset retinal
degeneration in humans. However, the pathogenesis remains largely unknown. There are …

Cilia, the hair-like protrusions that beat at high frequencies to propel a cell or move fluid
around are composed of radially bundled doublet microtubules. In this study, we present a …

Nephronophthisis (NPH) is an autosomal-recessive ciliopathy representing one of the most
frequent causes of kidney failure in childhood characterized by a broad clinical and genetic …

The propulsion for mammalian sperm swimming is generated by flagella beating.
Microtubule doublets (DMTs) along with microtubule inner proteins (MIPs) are essential …