ATP-binding cassette (ABC) transporters constitute one of the largest superfamilies of
conserved proteins from bacteria to mammals. In humans, three members of this family are …

Background There is an unmet need to develop therapeutic interventions directed at the
neurodegeneration that underlies progression in multiple sclerosis. High-dose …

Background Biotin may activate the acetyl-CoA-, 3-methylcrotonyl-CoA-, propionyl-CoA-,
and pyruvate carboxylases to increase myelin repair and/or synthesis, and may enhance the …

X-linked adrenoleukodystrophy (X-ALD), the most common peroxisomal disorder, is caused
by mutations in the peroxisomal transporter ABCD1, resulting in the accumulation of very …

The excess of free radicals causes numerous imbalances in the body that lead to premature
aging, the degradation of internal structures, and the appearance of numerous pathologies …

Aberrant endocannabinoid signaling accompanies several neurodegenerative disorders,
including multiple sclerosis. Here, we report altered endocannabinoid signaling in X-linked …

Abstract X-linked adrenoleukodystrophy (X-ALD) is an inherited neurodegenerative disorder
associated with mutations of the ABCD1 gene that encodes a peroxisomal transmembrane …

Aims Mitochondrial dysfunction and inflammation are at the core of axonal degeneration in
several multifactorial neurodegenerative diseases, including multiple sclerosis, Alzheimer's …

Biotin, also known as vitamin B7 or vitamin H, is a water-soluble B-complex vitamin and
serves as an essential co-enzyme for five specific carboxylases. Holocarboxylase synthase …

X-linked adrenoleukodystrophy (X-ALD) is an inherited disease caused by a mutation in the
ABCD1 gene encoding a peroxisomal transmembrane protein. It is characterized by the …