Cancer immunotherapy offers substantive benefit to patients with various tumour types, in
some cases leading to complete tumour clearance. However, many patients do not respond …

Interferon-gamma (IFN-γ) is a pleiotropic molecule with associated antiproliferative, pro-
apoptotic and antitumor mechanisms. This effector cytokine, often considered as a major …

Cytokines are a class of potent immunoregulatory proteins that are secreted in response to
various stimuli and act locally to regulate many aspects of human physiology and disease …

Several immune and immunocompetent cells, including dendritic cells, macrophages,
adipocytes, natural killer cells, T cells, and B cells, are significantly correlated with the …

Type I innate lymphoid cells (ILC1s) are critical regulators of inflammation and immunity in
mammalian tissues. However, their function in cancer is mostly undefined. Here, we show …

Background The sepsis-induced immunodepression contributes to impaired clinical
outcomes of various stress conditions. This syndrome is well documented and characterized …

Background: The up-regulation of PD-L1 is recognized as an adaption of cancer cells to
evade immune surveillance and attack. However, the intrinsic mechanisms of the induction …

The recent success of mRNA therapeutics against pathogenic infections has increased
interest in their use for other human diseases including cancer. However, the precise …

Interferons are a group of immunomodulatory substances produced by the human immune
system in response to the presence of pathogens, especially during viral and bacterial …

Cancer immunotherapy holds great potential to battle cancer by exerting a durable immunity
effect. However, this process might be limited by various constraints existing in the tumor …