The effectiveness of various chemotherapeutic agents in cancer treatment

J Kashifa Fathima, V Lavanya, S Jamal… - Current Pharmacology …, 2022 - Springer
Abstract Purpose of Review Cancer is one of the most life-threatening disease worldwide. It
affects people of all age groups. Various escape mechanisms are utilized by cancer cells …

Fusion of a novel native signal peptide enhanced the secretion and solubility of bioactive human interferon gamma glycoproteins in Nicotiana benthamiana using the …

MC Jiang, CC Hu, WL Hsu, TL Hsu, NS Lin… - Frontiers in Plant …, 2020 - frontiersin.org
Plant viruses may serve as expression vectors for the efficient production of pharmaceutical
proteins in plants. However, the downstream processing and post-translational modifications …

Oral Administration of Lactococcus lactis Producing Interferon Type II, Enhances the Immune Response Against Bacterial Pathogens in Rainbow Trout

A Santibañez, D Paine, M Parra, C Muñoz… - Frontiers in …, 2021 - frontiersin.org
Lactic acid bacteria are a powerful vehicle for releasing of cytokines and immunostimulant
peptides at the gastrointestinal level after oral administration. However, its therapeutic …

Иммуностимулирующий эффект Биферона-С на фоне медикаментозной профилактики болезней свиноматок и поросят в промышленном свиноводстве

СВ Шабунин, АГ Шахов, ГА Востроилова… - …, 2018 - cyberleninka.ru
Одна из основных причин высокой заболеваемости маточного поголовья свиней и их
потомства иммунодефициты, вызываемые воздействием на организм различных …

Artificial neural network‐genetic algorithm (ANN‐GA) based medium optimization for the production of human interferon gamma (hIFN‐γ) in Kluyveromyces lactis cell …

S Unni, AA Prabhu, R Pandey, R Hande… - … Canadian Journal of …, 2019 - Wiley Online Library
In the current investigation, we have adapted response surface methodology (RSM) and
artificial neural network‐genetic algorithm (ANN‐GA) based optimization to develop a …

IFN-γ establishes interferon-stimulated gene-mediated antiviral state against Newcastle disease virus in chicken fibroblasts

X Yang, M Arslan, X Liu, H Song, M Du… - Acta Biochimica et …, 2020 - academic.oup.com
Newcastle disease virus (NDV) causes severe economic losses through severe morbidity
and mortality and poses a significant threat to the global poultry industry. Significant efforts …

Executable network of SARS-CoV-2-host interaction predicts drug combination treatments

R Howell, MA Clarke, AK Reuschl, T Chen… - NPJ Digital …, 2022 - nature.com
The COVID-19 pandemic has pushed healthcare systems globally to a breaking point. The
urgent need for effective and affordable COVID-19 treatments calls for repurposing …

A novel reverse micellar purification strategy for histidine tagged human interferon gamma (hIFN-γ) protein from Pichia pastoris

AA Prabhu, A Purkayastha, B Mandal, JP Kumar… - International journal of …, 2018 - Elsevier
In the present study, we have demonstrated the process development of human interferon
gamma (hIFN-γ)(upstream to downstream). The codon optimized hIFN-γ gene was cloned in …

[HTML][HTML] Intra-tumoral heterogeneity and immune responses predicts prognosis of gastric cancer

W Feng, Y Wang, S Chen, X Zhu - Aging (albany NY), 2020 - ncbi.nlm.nih.gov
Chemotherapy resistance eventually develops in patients with gastric cancer (GC). Intra-
tumoral heterogeneity (ITH) refers to the intercellular genetic variations and phenotypic …

Improved therapeutic efficacy of mammalian expressed-recombinant interferon gamma against ovarian cancer cells

A Razaghi, C Villacrés, V Jung, N Mashkour… - Experimental cell …, 2017 - Elsevier
Human interferon gamma (hIFNγ) affects tumour cells and modulates immune responses,
showing promise as an anti-cancer biotherapeutic. This study investigated the effect of …