Ph1-positive leukaemia, including chronic myelogenous leukaemia

JD ROWLEY - Clinics in haematology, 1980 - Elsevier
Cytogenetic studies on patients with chronic myelogenous leukaemia (CML) have been the
keystone for karyotype analysis ofother human malignancies. New discoveries that have …

Clustering of aberrations to specific chromosomes in human neoplasms: IV. A survey of 1,871 cases

F MITELMAN, G LEVAN - Hereditas, 1981 - Wiley Online Library
This survey of chromosomal aberrations in human neoplasms comprises 1,871 cases
distributed on 15 groups of malignant disease, viz. 4 groups of myeloproliferative disorders …

Phenotypical characteristics of acute myelocytic leukemia associated with the t (8; 21)(q22; q22) chromosomal abnormality: frequent expression of immature B-cell …

K Kita, K Nakase, H Miwa, M Masuya, K Nishii, N Morita… - 1992 - ashpublications.org
Twenty-three acute myelocytic leukemia (AML) patients with t (8; 21) chromosomal
abnormality, all classified as M2 (French-American-British [FAB] classification), were …

Cellular Characteristics of Acute Myeloblasts Leukemia Associated with t (8; 21)(q22; q22)

K Kita, S Shirakawa, N Kamadat - Leukemia & Lymphoma, 1994 - Taylor & Francis
A large number of AML cases is reviewed in order to clarify biological characteristics of t (8;
21) AML cells. The incidence of positivities for stem cell antigens, CD34 and HLA-DR, on …

Inversion of chromosome 16 and bone marrow eosinophilia in a myelomonocytic transformation of chronic myeloid leukemia

N Asou, I Sanada, K Tanaka, M Hidaka… - Cancer genetics and …, 1992 - Elsevier
We report a case of chronic myeloid leukemia (CML) in myelomonocytic transformation
associated with bone marrow (BM) eosinophilia. At diagnosis, all BM cells showed a Ph …

Philadelphia-positive acute leukemia: cytogenetic and molecular aspects

R Berger, SJ Chen, Z Chen - Cancer genetics and cytogenetics, 1990 - Elsevier
The Philadelphia chromosome (Ph)[1] was initially believed to be specific for chronic
myelogenous leukemia (CML). When chromosome banding techniques were introduced, it …

Ph-positive chronic myeloid leukemia with t (8; 21)(q22; q22) in blastic crisis

MT Ferro, JL Steegman, L Escribano… - Cancer genetics and …, 1992 - Elsevier
A patient diagnosed with chronic myeloid leukemia was studied periodically during his
illness. The result showed the presence of a Philadelphia (Ph) chromosome by a 9; 22 …

A case of basophilic leukemia bearing simultaneous translocations t (8; 21) and t (9; 22)

Y Xue, Y Guo, D Lu, J Gu, D Lu, J Gong, M Wang… - Cancer genetics and …, 1991 - Elsevier
We report a case of basophilic leukemia with simultaneous translocations of t (8; 21) and t
(9; 22). The patient's clinical and hematologic findings were characteristic only of t (9; 22) but …

Acquisition of the Ph chromosome and BCR-ABL fusion product in AML-M2 and t (8; 21) leukemia: cytogenetic and FISH evidence for a late event

V Najfeld, M Geller, K Troy, A Scalise - Leukemia, 1998 - nature.com
A patient with the M2 subtype of AML who had a 45, X,− X, t (8; 21) karyotype at diagnosis
was found to have the Ph chromosome in one out of 37 evaluated cells 18 months after the …

Development of t (8; 21) and RUNX1–RUNX1T1 in the Philadelphia-positive clone of a patient with chronic myelogenous leukemia: additional evidence for multiple …

V Najfeld, N Wisch, J Mascarenhas, L Issa, J Tripodi… - Cancer Genetics, 2011 - Elsevier
A 65-year-old patient with a high hemoglobin and hematocrit was treated for 14 months with
therapeutic phlebotomy when cytogenetics of bone marrow revealed 100% cells with the Ph …