Adenosine monophosphate-activated protein kinase (AMPK) is a key metabolic sensor that
is pivotal for the maintenance of cellular energy homeostasis. AMPK contributes to diverse …

Small-cell lung cancer (SCLC) is an aggressive lung cancer subtype and its first-line
treatment has remained unchanged for decades. In recent years, immunotherapy has …

Simple Summary Cancer is one of the most debated problems all over the world. Cancer
stem cells are considered responsible of tumor initiation, metastasis, drug resistance, and …

Although Warburg's discovery of intensive glucose uptake by tumors, followed by lactate
fermentation in oxygen presence of oxygen was made a century ago, it is still an area of …

Methyl gallate (MG) is a polyphenolic compound widely found in natural plants. MG has
been shown to have a variety of biological functions, including anti-tumor, anti-inflammatory …

Tumor microenvironment (TME), which is characterized by hypoxia, widely exists in solid
tumors. As a current research hotspot in the TME, hypoxia is expected to become a key …

Despite the remarkable progress in cancer treatment up to now, we are still far from
conquering the disease. The most substantial change after the malignant transformation of …

Background: Tumorigenesis is associated with deregulation of nutritional requirements,
intermediary metabolites production, and microenvironment interactions. Unlike their normal …

Fasting mimicking diets (FMDs) are emerging as effective dietary interventions with the
potential to improve healthspan and decrease the incidence of cancer and other age-related …

Metabolic disturbance, particularly of glucose metabolism, is a hallmark of tumors such as
non-small cell lung cancer (NSCLC). Cancer cells tend to reprogram a majority of glucose …