Acute central nervous system (CNS) injuries, including ischemic stroke, traumatic brain
injury (TBI), spinal cord injury (SCI) and subarachnoid hemorrhage (SAH), are the most …

Impaired ribosome function is the underlying etiology in a group of bone marrow failure
syndromes called ribosomopathies. However, how ribosomes are regulated remains poorly …

The cell cycle is tightly regulated by protein phosphorylation and ubiquitylation events.
During mitosis, the multi-subunit cullin-RING E3 ubiquitin ligase APC/c functions as a …

Background Proteome characterization of the porcine endometrium and extraembryonic
membranes is important to understand mother-embryo cross-communication. In this study …

Ulcerative colitis (UC) is a persistent inflammatory condition affecting the colon's mucosal
lining, leading to chronic bowel inflammation. Despite extensive research, the precise …

As a transcription factor, SNAIL plays a crucial role in embryonic development and cancer
progression by mediating epithelial‑mesenchymal transition (EMT); however, post …

Renal cell carcinoma (RCC) is a frequent malignancy of the urinary system. It has been
found that hypoxia mediates the malignant evolvement of RCC. Here, we probe the impact …

Excitatory neurotoxicity caused by the accumulation of glutamate in the synaptic cleft is an
important cause of Parkinson's disease (PD). Astrocyte glutamate transporter 1 (GLT-1) is …

Growing evidence has demonstrated the emerging role of long non-coding RNA as
competitive endogenous RNA (ceRNA) in regulating skeletal muscle development …

Neural tube defects (NTDs) are severe malformations of the central nervous system that
arise from failure of neural tube closure. HECTD1 is an E3 ubiquitin ligase required for …