Endothelial cells (ECs) constitute the innermost layer in all blood vessels to maintain the
structural integrity and microcirculation function for coronary microvasculature. Impaired …

Sirtuins are class III histone deacetylases, whose enzymatic activity is dependent on NAD+
as a cofactor. Sirtuins are reported to modulate numerous activities by controlling gene …

Cardiometabolic diseases (CMDs) are metabolic diseases (eg, obesity, diabetes,
atherosclerosis, rare genetic metabolic diseases, etc.) associated with cardiac pathologies …

Polyphenols are secondary metabolites produced by plants, which contribute to the plant's
defense against abiotic stress conditions (eg, UV radiation and precipitation), the aggression …

Obesity is a risk factor that leads to the development of other diseases such as dyslipidemia
and diabetes. These three metabolic disorders can occur simultaneously, hence, the …

Polyphenols are the general designation of various kinds of phytochemicals, mainly
classified as flavonoids and nonflavonoids. Polyphenolic compounds have been confirmed …

Resveratrol is a naturally occurring non-flavonoid polyphenol which is found in a variety of
plants, where it responses to the injury or fungal attack. This important compound has …

Nicorandil exerts myocardial protection through its antihypoxia and antioxidant effects. Here,
we investigated whether it plays an anti‐apoptotic role in diabetic cardiomyopathy. Sprague …

Myocardial ischemia/reperfusion injury (MI/RI) is the main cause of deaths in the worldwide,
leading to severe cardiac dysfunction. Resveratrol (RSV) is a polyphenol plant‐derived …

Obesity‐induced insulin resistance and type 2 diabetes mellitus can ultimately result in
various complications, including diabetic cardiomyopathy. In this case, cardiac dysfunction is …