Human anxiety disorders are broadly grouped according to symptomology and
responsiveness to pharmacological and psychological treatment [1, 2]. Generalized anxiety …

• A carbon dioxide hypersensitivity theory of panic has been posited. We hypothesize more
broadly that a physiologic misinterpretation by a suffocation monitor misfires an evolved …

A model of the neuropsychology of anxiety is proposed. The model is based in the first
instance upon an analysis of the behavioural effects of the antianxiety drugs …

In the field of anxiety research, animal models are used as screening tools in the search for
compounds with therapeutic potential and as simulations for research on mechanisms …

The amino acid γ-aminobutyric-acid (GABA) prevails in the CNS as an inhibitory neurotrans-
mitter that mediates most of its effects through fast GABA-gated Cl−-channels (GABA AR) …

A single prior undrugged exposure to the elevated plus-maze has been reported to reduce
open arm activity on retest and to attenuate/abolish the anxiolytic response to …

• The possibility that panic disorder might be due to abnormal activity of endogenous ligands
of the benzodiazepine receptor was investigated with the use of the benzodiazepine …

The effects of manipulating 5-hydroxytryptamine (5HT) neuronal function in humans and in
animals are reviewed. 5HT pathways do not have a unitary function in modulating anxiety. It …

The study of carbon dioxide (CO2) inhalation in psychiatry has a long and varied history,
with recent interest in using inhaled CO2 as an experimental tool to explore the …

Behavioral, endocrinological, and pharmacological data suggest that the emotional
response of rodents to the elevated plus-maze alters as a function of prior test experience. In …