Cullin–RING complexes comprise the largest known class of ubiquitin ligases. Owing to the
great diversity of their substrate-receptor subunits, it is possible that there are hundreds of …

The SCF (Skp1–Cullin–F-box) E3 ubiquitin ligase family was discovered through genetic
requirements for cell cycle progression in budding yeast. In these multisubunit enzymes, an …

The concentrations and functions of many eukaryotic proteins are regulated by the ubiquitin
pathway, which consists of ubiquitin activation (E1), conjugation (E2), and ligation (E3) …

It is generally assumed that a specific ubiquitin ligase (E3) links protein substrates to
polyubiquitin chains containing a single type of isopeptide linkage, and that chains …

The concentrations and functions of many cellular proteins are regulated by the ubiquitin
pathway. Cullin family proteins bind with the RING-finger protein Roc1 to recruit the ubiquitin …

This review summarizes recent advances concerning the Nedd8 regulatory pathway in four
areas. One, substantial progress has been made in delineating the role of cullin family …

Cullin‐based E3 ligases target substrates for ubiquitin‐dependent degradation by the 26S
proteasome. The SCF (Skp1–Cul1–F‐box) and ECS (ElonginC–Cul2–SOCS box) …

The role of protein ubiquitylation in the control of diverse cellular pathways has recently
gained widespread attention. Ubiquitylation not only directs the targeted destruction of …

Cullin proteins assemble a large number of RING E3 ubiquitin ligases and regulate various
physiological processes. Covalent modification of cullins by the ubiquitin-like protein …

Cullins assemble a potentially large number of ubiquitin ligases by binding to the RING
protein ROC1 to catalyse polyubiquitination, as well as binding to various specificity factors …