Acoustic waves are induced via the thermoacoustic effect in objects exposed to a pulsed
beam of ionizing radiation. This phenomenon has interesting potential applications in both …

We present a full-scale clinical prototype system for in vivo range verification of proton pencil-
beams using the prompt gamma-ray spectroscopy method. The detection system consists of …

Purpose To investigate if radiographic imaging changes defined as necrosis correlate with
regions in the brain with elevated linear energy transfer (LET) for proton radiation therapy …

The cellular response to ionizing radiation continues to be of significant research interest in
cancer radiotherapy, and DNA is recognized as the critical target for most of the biologic …

For radiotherapy, it is crucial to guarantee that the delivered dose matches the planned
dose. Therefore, patient specific quality assurance (QA) of absolute dose distributions is …

The lateral fall-off is crucial for sparing organs at risk in proton therapy. It is therefore of high
importance to minimize the penumbra for pencil beam scanning (PBS). Three optimisation …

Purpose Uncertainties in relative biological effectiveness (RBE) constitute a major pitfall of
the use of protons in clinics. An RBE value of 1.1, which is based on cell culture and animal …

Objectives: Software re-calculation of proton pencil beam scanning plans provides a method
of verifying treatment planning system (TPS) dose calculations prior to patient treatment …

The clinical implementation of a variable relative biological effectiveness (RBE) in proton
therapy is currently controversially discussed. Initial clinical evidence indicates a variable …

For the independent validation of treatment plans, we developed a fully automated Monte
Carlo (MC)-based patient dose calculation system with the tool for particle simulation …