Aging is driven by hallmarks fulfilling the following three premises:(1) their age-associated
manifestation,(2) the acceleration of aging by experimentally accentuating them, and (3) the …

Both aging and cancer are characterized by a series of partially overlapping" hallmarks" that
we subject here to a meta-analysis. Several hallmarks of aging (ie, genomic instability …

Age is the key risk factor for diseases and disabilities of the elderly. Efforts to tackle age-
related diseases and increase healthspan have suggested targeting the ageing process …

Aging is characterized by a progressive deterioration of physiological integrity, leading to
impaired functional ability and ultimately increased susceptibility to death. It is a major risk …

The mammalian brain is complex, with multiple cell types performing a variety of diverse
functions, but exactly how each cell type is affected in aging remains largely unknown. Here …

FOXO proteins are transcription factors that are involved in numerous physiological
processes and in various pathological conditions, including cardiovascular disease, cancer …

Dietary restriction (DR) decreases body weight, improves health, and extends lifespan. DR
can be achieved by controlling how much and/or when food is provided, as well as by …

Pacific Ocean rockfishes (genus Sebastes) exhibit extreme variation in life span, with some
species being among the most long-lived extant vertebrates. We de novo assembled the …

Cellular senescence is an irreversible state of cell cycle arrest occurring in response to
stressful stimuli, such as telomere attrition, DNA damage, reactive oxygen species, and …

Forkhead box (FOX) O proteins are transcription factors (TFs) with four members in
mammals designated FOXO1, FOXO3, FOXO4, and FOXO6. FOXO TFs play a pivotal role in …