Background Despite the progress in comprehending molecular design principles and
biochemical processes associated with thrombin inhibition, there is a crucial need to …

Abstract Background and Objective Real-life data about the use of dabigatran in patients
with non-valvular atrial fibrillation are warranted. The objective of this systematic review and …

The lethality of patients with ovarian cancer (OC) remains high. Current treatment strategies
often do not lead to the desired outcome due to the development of therapy resistance …

Thrombosis is a life-threatening disease with a high mortality rate in many countries. Even
though anti-thrombotic drugs are available, their serious side effects compel the search for …

The present article provides an overview of our work related to cyclization reactions of nitro-
substituted electrophilic building blocks with various nucleophiles. As electrophiles, we used …

Venous thromboembolism, which encompasses deep venous thrombosis and pulmonary
embolism is one of the most common causes of morbidity and mortality. Management of …

Venous thromboembolic disease, which includes pulmonary thromboembolism and deep
vein thrombosis, is one of the most common causes of morbidity and mortality. Management …

Long-term oral anticoagulation is a cornerstone of stroke prevention in patients with atrial
fibrillation (AF). Patient education should be provided regarding the need for anticoagulant …

ABSTRACT Introduction: Direct oral anticoagulants (DOACs) constitute a first-line therapy in
non-valvular atrial fibrillation and venous thromboembolic disease. The aim of this study was …

Purpose: To assess the comparative effectiveness and safety of dabigatran‒globally and
stratified by dose (110 or 150 mg bid) compared to vitamin K antagonists (VKA) in patients …