Principles of molecular testing for hereditary cancer

C Mighton, JP Lerner‐Ellis - Genes, Chromosomes and Cancer, 2022 - Wiley Online Library
Molecular testing for hereditary cancers has rapidly advanced over the past two decades.
Next‐generation sequencing has been widely adopted, which has made molecular testing …

Racial disparity in the genomics of precision oncology of prostate cancer

T Le, PS Rojas, M Fakunle, FW Huang - Cancer Reports, 2023 - Wiley Online Library
Background Significant racial disparities in prostate cancer incidence and mortality have
been reported between African American Men (AAM), who are at increased risk for prostate …

[HTML][HTML] Clinical utility of polygenic risk scores: a critical 2023 appraisal

S Koch, J Schmidtke, M Krawczak… - Journal of Community …, 2023 - Springer
Since their first appearance in the context of schizophrenia and bipolar disorder in 2009,
polygenic risk scores (PRSs) have been described for a large number of common complex …

Polygenic risk score in prostate cancer

JJ Oh, SK Hong - Current Opinion in Urology, 2022 - journals.lww.com
Emerging data from several studies regarding PRS in PCa could be the solution to adding
predictive value to PCa risk estimation. Although commercial markers are available …

[HTML][HTML] Dose outside of the prostate is associated with improved outcomes for high-risk prostate cancer patients treated with brachytherapy boost

J Shortall, E Vasquez Osorio, A Green… - Frontiers in …, 2023 - frontiersin.org
Background: One in three high-risk prostate cancer patients treated with radiotherapy recur.
Detection of lymph node metastasis and microscopic disease spread using conventional …

Genome‑wide association study and polygenic risk scores predict psoriasis and its shared phenotypes in Taiwan

JS Yang, TY Liu, HF Lu, SC Tsai… - Molecular …, 2024 - spandidos-publications.com
Psoriasis is a chronic inflammatory dermatological disease, and there is a lack of
understanding of the genetic factors involved in psoriasis in Taiwan. To establish …

How do experts in psychiatric genetics view the clinical utility of polygenic risk scores for schizophrenia?

T Moorthy, H Nguyen, Y Chen, J Austin… - American Journal of …, 2023 - Wiley Online Library
Polygenic risk scores (PRS) are promising for identifying common variant‐related
inheritance for psychiatric conditions but their integration into clinical practice depends on …

[图书][B] Exploring and Exploiting Genetic Risk for Psychiatric Disorders

JA Gordon, E Binder - 2023 - books.google.com
An edited volume that looks at the state of psychiatric genetics and how to chart a path
forward. In this edited collection, experts from psychiatric and statistical genetics …

[HTML][HTML] The Combined Effect of Polygenic Risk Score and Prostate Health Index in Chinese Men Undergoing Prostate Biopsy

X Ruan, D Huang, J Huang, J Huang, Y Zhan… - Journal of Clinical …, 2023 - mdpi.com
To date, the combined effect of polygenic risk score (PRS) and prostate health index (phi) on
PCa diagnosis in men undergoing prostate biopsy has never been investigated. A total of …

Racial Disparity in Utilizing Genetic Testing for Personalized Care of Prostate Cancer

T Le, PS Rojas, M Fakunle, F Huang - Authorea Preprints, 2023 - techrxiv.org
Significant racial disparities in prostate cancer incidence and mortality have been reported
between African American Men (AAM) who are at increased risk for prostate cancer, and …