Genetic engineering of pigs for xenotransplantation to overcome immune rejection and physiological incompatibilities: the first clinical steps

T Lei, L Chen, K Wang, S Du… - Frontiers in …, 2022 - frontiersin.org
Xenotransplantation has the potential to solve the shortfall of human organ donors.
Genetically modified pigs have been considered as potential animal donors for human …

Advances in organ and tissue xenotransplantation

A Ali, E Kemter, E Wolf - Annual Review of Animal Biosciences, 2024 - annualreviews.org
End-stage organ failure can result from various preexisting conditions and occurs in patients
of all ages, and organ transplantation remains its only treatment. In recent years, extensive …

The attenuated African swine fever vaccine HLJ/18-7GD provides protection against emerging prevalent genotype II variants in China

Z Wang, J Zhang, F Li, Z Zhang, W Chen… - Emerging Microbes & …, 2024 - Taylor & Francis
Genetic changes have occurred in the genomes of prevalent African swine fever viruses
(ASFVs) in the field in China, which may change their antigenic properties and result in …

Decellularized-disc based allograft and xenograft prosthesis for the long-term precise reconstruction of temporomandibular joint disc

N Jiang, H Chen, J Zhang, P Cao, P Wang, Y Hou… - Acta biomaterialia, 2023 - Elsevier
Currently, no effective disc reconstruction treatment strategy is clinically available for
temporomandibular joint (TMJ) disc-related diseases. To address this, we developed a …

Liver and hepatocyte transplantation: what can pigs contribute?

X Li, Y Wang, H Yang, Y Dai - Frontiers in Immunology, 2022 - frontiersin.org
About one-fifth of the population suffers from liver diseases in China, meaning that liver
disorders are prominent causative factors relating to the Chinese mortality rate. For patients …

Mitigating cross-species viral infections in xenotransplantation: progress, strategies, and clinical outlook

Y Zhou, S Zhou, Q Wang, B Zhang - Cell Transplantation, 2024 - journals.sagepub.com
Xenotransplantation holds great promise as a solution to address the critical shortage of
organs, but it raises concerns regarding the potential transmission of porcine viruses to …

[PDF][PDF] Genetically-engineered pig-to-human organ transplantation: a new beginning

X Zhang, DKC Cooper, K Dou - Science bulletin, 2022 - Elsevier
There has been a continuing inadequate number of human organs for the treatment of
patients with terminal organ failure worldwide. The transplantation of organs from genetically …

Meeting report: xenotransplantation development conference in Neijiang, China

G Huai, HJ Schuurman, DKC Cooper… - …, 2023 - Wiley Online Library
A conference on progress in the development of xenotransplantation in China was held in
Neijiang, Sichuan, in May 2023, and was attended by approximately 100 established …

Unaddressed regulatory issues in xenotransplantation: a hypothetical example

K Kwisda - Frontiers in Transplantation, 2023 - frontiersin.org
The last few years have seen a significant increase in the use of technology to manipulate
genetic sequences and generate animals as a source of xeno-organs. This has made the …

临床异种器官移植十大问题的思考.

窦科峰, 张玄 - Organ Transplantation/Qi Guan Yi Zhi, 2022 - search.ebscohost.com
供者短缺是影响器官移植发展的一大难题, 而异种器官移植可能是解决这一难题的有效途径.
随着基因编辑技术的发展以及新型免疫抑制剂的研发, 异种器官移植领域取得了许多突破性的 …