[HTML][HTML] Recent advances on quinazoline derivatives: A potential bioactive scaffold in medicinal chemistry
This paper intended to explore and discover recent therapeutic agents in the area of
medicinal chemistry for the treatment of various diseases. Heterocyclic compounds …
medicinal chemistry for the treatment of various diseases. Heterocyclic compounds …
An appraisal of anticancer activity with structure–activity relationship of quinazoline and quinazolinone analogues through EGFR and VEGFR inhibition: A review
Cancer is one of the leading causes of death. Globally a huge number of deaths and new
incidences are reported annually. Heterocyclic compounds have been proved to be very …
incidences are reported annually. Heterocyclic compounds have been proved to be very …
Design, synthesis and evaluation of new quinazolin-4-one derivatives as apoptotic enhancers and autophagy inhibitors with potent antitumor activity
HSA ElZahabi, MS Nafie, D Osman… - European Journal of …, 2021 - Elsevier
This work presents the design and synthesis of a series of new quinazolin-4-one derivatives,
based on the established effectiveness of quinazoline-based small molecules as anticancer …
based on the established effectiveness of quinazoline-based small molecules as anticancer …
Synthesis, characterization and molecular docking studies of highly selective new hydrazone derivatives of anthranilic acid and their ring closure analogue Quinazolin …
In this study, new Schiff bases derived from anthranilic acid hydrazide (3a-j) and quinazolin-
4 (3H)-one (4a-j) were synthesized with high yields (99-90%) and characterized by FTIR …
4 (3H)-one (4a-j) were synthesized with high yields (99-90%) and characterized by FTIR …
Epidermal growth factor receptor inhibitors as potential anticancer agents: An update of recent progress
Epidermal growth factor receptor (EGFR) is a vital intermediate in cell signaling pathway
including cell proliferation, angiogenesis, apoptosis, and metastatic spread and also having …
including cell proliferation, angiogenesis, apoptosis, and metastatic spread and also having …
[HTML][HTML] Cell cycle arrest and apoptosis-inducing ability of benzimidazole derivatives: design, synthesis, docking, and biological evaluation
S Nazreen, ASA Almalki, SEI Elbehairi, AA Shati… - Molecules, 2022 - mdpi.com
In the current study, new benzimidazole-based 1, 3, 4-oxadiazole derivatives have been
synthesized and characterized by NMR, IR, MS, and elemental analysis. The final …
synthesized and characterized by NMR, IR, MS, and elemental analysis. The final …
[HTML][HTML] Suppression Effect of Ulva lactuca Selenium Nanoparticles (USeNPs) on HepG2 Carcinoma Cells Resulting from Degradation of Epidermal Growth Factor …
MEM Makhlof, FM Albalwe, TM Al-Shaikh… - Applied Sciences, 2022 - mdpi.com
The current study sought to assess the antitumor, anticancer, and antioxidant efficacy of Ulva
lactuca-mediated selenium nanoparticles by using an in vitro model of human …
lactuca-mediated selenium nanoparticles by using an in vitro model of human …
Recent advances in nitrogen-containing heterocyclic compounds as receptor tyrosine kinase inhibitors for the treatment of cancer: Biological activity and structural …
Erratic cell proliferation is the initial symptom of cancer, which can eventually metastasize to
other organs. Before cancer becomes metastatic, its spread is triggered by pro-angiogenic …
other organs. Before cancer becomes metastatic, its spread is triggered by pro-angiogenic …
Discovery of a novel series of substituted quinolines acting as anticancer agents and selective EGFR blocker: Molecular docking study
Abstract A Ta 2 O 5-anchored-piperidine-4-carboxylic acid (PPCA) nanoparticle has been
synthesized and characterized. It was then used as a highly effective nanocatalyst for the …
synthesized and characterized. It was then used as a highly effective nanocatalyst for the …
Applications of medicinal chemistry for drug discovery against Acanthamoeba infections
Acanthamoeba is a genus of free‐living amoebae, pervasively found in the environment.
Most of its pathogenic species are the causative agent of sight‐threatening Acanthamoeba …
Most of its pathogenic species are the causative agent of sight‐threatening Acanthamoeba …