Urine in clinical proteomics

S Decramer, AG de Peredo, B Breuil, H Mischak… - Molecular & cellular …, 2008 - ASBMB
Urine has become one of the most attractive biofluids in clinical proteomics as it can be
obtained non-invasively in large quantities and is stable compared with other biofluids. The …

Technical aspects and inter-laboratory variability in native peptide profiling: The CE–MS experience

H Mischak, A Vlahou, JPA Ioannidis - Clinical biochemistry, 2013 - Elsevier
Mass spectrometry platforms have attracted a lot of interest in the last 2 decades as profiling
tools for native peptides and proteins with clinical potential. However, limitations associated …

Capillary electrophoresis mass spectrometry-based saliva metabolomics identified oral, breast and pancreatic cancer-specific profiles

M Sugimoto, DT Wong, A Hirayama, T Soga, M Tomita - Metabolomics, 2010 - Springer
Saliva is a readily accessible and informative biofluid, making it ideal for the early detection
of a wide range of diseases including cardiovascular, renal, and autoimmune diseases, viral …

Naturally occurring human urinary peptides for use in diagnosis of chronic kidney disease

DM Good, P Zürbig, A Argiles, HW Bauer… - Molecular & cellular …, 2010 - ASBMB
Because of its availability, ease of collection, and correlation with physiology and pathology,
urine is an attractive source for clinical proteomics/peptidomics. However, the lack of …

Advances in urinary proteome analysis and biomarker discovery

D Fliser, J Novak, V Thongboonkerd… - Journal of the …, 2007 - journals.lww.com
Noninvasive diagnosis of kidney diseases and assessment of the prognosis are still
challenges in clinical nephrology. Definition of biomarkers on the basis of proteome …

Clinical proteomics: a need to define the field and to begin to set adequate standards

H Mischak, R Apweiler, RE Banks… - PROTEOMICS …, 2007 - Wiley Online Library
The aim of this manuscript is to initiate a constructive discussion about the definition of
clinical proteomics, study requirements, pitfalls and (potential) use. Furthermore, we hope to …

CE‐MS analysis of the human urinary proteome for biomarker discovery and disease diagnostics

JJ Coon, P Zürbig, M Dakna… - Proteomics–Clinical …, 2008 - Wiley Online Library
Owing to its availability, ease of collection, and correlation with pathophysiology of diseases,
urine is an attractive source for clinical proteomics. However, many proteomic studies have …

Decoupling CE and ESI for a more robust interface with MS

EJ Maxwell, X Zhong, H Zhang, N van Zeijl… - …, 2010 - Wiley Online Library
An interface for CE‐ESI‐MS that decouples both the electrical and the solution flow rate
requirements of the separation and ionization processes is presented. The interface uses a …

Recent advances in capillary electrophoresis coupled to mass spectrometry for clinical proteomic applications

A Stalmach, A Albalat, W Mullen, H Mischak - Electrophoresis, 2013 - Wiley Online Library
Proteome analysis using capillary electrophoresis coupled to mass spectrometry (CE‐MS)
has been used in a number of clinical applications in the past years. The main focus of CE …

Capillary electrophoresis of proteins 2005–2007

V Dolník - Electrophoresis, 2008 - Wiley Online Library
This review article with 239 references describes recent developments in capillary
electrophoresis of proteins, and covers the two years since the previous review (V. Dolník …