▪ Abstract The phosphoinositide 3-kinase (PI3K) family of enzymes is recruited upon growth
factor receptor activation and produces 3′ phosphoinositide lipids. The lipid products of …

▪ Abstract The 3-phosphorylated inositol lipids fulfill roles as second messengers by
interacting with the lipid binding domains of a variety of cellular proteins. Such interactions …

The tumor suppressor PTEN regulates cell migration, growth, and survival by removing the
3′-phosphate of phosphoinositides. Exposure of purified PTEN or of cells to H 2 O 2 …

The roles of the JAK/STAT, Raf/MEK/ERK and PI3K/Akt signal transduction pathways and
the BCR-ABL oncoprotein in leukemogenesis and their importance in the regulation of cell …

The tumor suppressor phosphatase PTEN regulates cell migration, growth, and survival by
dephosphorylating phosphatidylinositol second messengers and signaling …

PTEN (also known as MMAC-1 or TEP-1) is one of the most frequently mutated tumor
suppressors in human cancer. It is also essential for embryonic development. PTEN …

It is widely accepted that reactive oxygen species (ROS) promote tumorigenesis. However,
the exact mechanisms are still unclear. As mice lacking the peroxidase peroxiredoxin1 …

The PTEN (phosphatase and tensin homologue deleted on chromosome 10) tumour
suppressor is a PI (phosphoinositide) 3-phosphatase that can inhibit cellular proliferation …

The PTEN tumour suppressor protein is a phosphoinositide 3-phosphatase that, by
metabolising phosphatidylinositol 3, 4, 5-trisphosphate (PtdIns (3, 4, 5) P3), acts in direct …

▪ Abstract Protein tyrosine phosphatases (PTPs) are a diverse group of enzymes that contain
a highly conserved active site motif, Cys-x5-Arg (Cx5R). The PTP super-family enzymes …