[HTML][HTML] Nanocarriers based on bacterial membrane materials for cancer vaccine delivery

X Zhao, R Zhao, G Nie - Nature protocols, 2022 - nature.com
Here we present a protocol for the construction and use of two types of nanocarrier based on
bacterial membrane materials for cancer vaccine delivery. Cancer vaccines induce tumor …

Polymeric long-acting drug delivery systems (LADDS) for treatment of chronic diseases: Inserts, patches, wafers, and implants

H Abdelkader, Z Fathalla, A Seyfoddin… - Advanced drug delivery …, 2021 - Elsevier
Non-oral long-acting drug delivery systems (LADDS) encompass a range of technologies for
precisely delivering drug molecules into target tissues either through the systemic circulation …

Bacterial cytoplasmic membranes synergistically enhance the antitumor activity of autologous cancer vaccines

L Chen, H Qin, R Zhao, X Zhao, L Lin, Y Chen… - Science translational …, 2021 - science.org
Cancer vaccines based on resected tumors from patients have gained great interest as an
individualized cancer treatment strategy. However, eliciting a robust therapeutic effect with …

Trial watch: Dendritic cell (DC)-based immunotherapy for cancer

RS Laureano, J Sprooten, I Vanmeerbeerk… - …, 2022 - Taylor & Francis
Dendritic cell (DC)-based vaccination for cancer treatment has seen considerable
development over recent decades. However, this field is currently in a state of flux toward …

[HTML][HTML] Exosomes: promising delivery tools for overcoming blood-brain barrier and glioblastoma therapy

SH Khatami, N Karami, M Taheri-Anganeh… - Molecular …, 2023 - Springer
Gliomas make up virtually 80% of all lethal primary brain tumors and are categorized based
on their cell of origin. Glioblastoma is an astrocytic tumor that has an inferior prognosis …

A phase I study of autologous dendritic cell vaccine pulsed with allogeneic stem-like cell line lysate in patients with newly diagnosed or recurrent glioblastoma

JL Hu, OA Omofoye, JD Rudnick, S Kim… - Clinical Cancer …, 2022 - AACR
Purpose: Glioblastoma (GBM) is a heterogeneous malignancy with multiple subpopulations
of cancer cells present within any tumor. We present the results of a phase I clinical trial …

[HTML][HTML] Immune escape in glioblastoma multiforme and the adaptation of immunotherapies for treatment

JRD Pearson, S Cuzzubbo, S McArthur… - Frontiers in …, 2020 - frontiersin.org
Glioblastoma multiforme (GBM) is the most frequently occurring primary brain tumor and has
a very poor prognosis, with only around 5% of patients surviving for a period of 5 years or …

[HTML][HTML] Personalised therapeutic approaches to glioblastoma: A systematic review

OD Mowforth, J Brannigan, M El Khoury… - Frontiers in …, 2023 - frontiersin.org
Introduction Glioblastoma is the most common and malignant primary brain tumour with
median survival of 14.6 months. Personalised medicine aims to improve survival by …

[HTML][HTML] Randomized controlled immunotherapy clinical trials for GBM challenged

SW Van Gool, J Makalowski, S Fiore, T Sprenger… - Cancers, 2020 - mdpi.com
Simple Summary Although multiple meta-analyses on active specific immunotherapy
treatment for glioblastoma multiforme (GBM) have demonstrated a significant prolongation of …

[HTML][HTML] Immunotherapy for recurrent glioblastoma: practical insights and challenging prospects

X Wang, J Lu, G Guo, J Yu - Cell Death & Disease, 2021 - nature.com
Glioblastoma (GB) is the most common high-grade intracranial malignant tumor with highly
malignant biological behavior and a high recurrence rate. Although anti-PD-1/PD-L1 …