All nations which have undergone a nutrition transition have experienced increased
frequency and falling latency of chronic degenerative diseases, which are largely driven by …

By rapidly modulating neuronal excitability, neurosteroids regulate physiological processes,
such as responses to stress and development. Excessive stress affects their biosynthesis …

This review highlights early efforts to translate pre-clinical and clinical findings regarding the
role of neuroactive steroids in stress adaptation and PTSD into new therapeutics for PTSD …

Background: Elderly patients in general exhibit a higher incidence of chronic and
neuropathic pain conditions. This group poses a particular clinical challenge due to age …

Fear is an emotion that serves as a driving factor in how organisms move through the world.
In this review, we discuss the current understandings of the subjective experience of fear …

Novel hypotheses suggest that antidepressants, such as the selective serotonin reuptake
inhibitor fluoxetine, induce neuronal structural plasticity, resembling that of the juvenile …

Background Primary negative symptoms of schizophrenia are usually resistant to
monotherapy with antipsychotics. The present study sought to assess the efficacy and …

Chemotherapy-induced peripheral neuropathy (CIPN) is a common complication of
antineoplastic drugs, particularly paclitaxel (PTX). It can affect the quality of patients' lives …

Aim Palmitoylethanolamide is an endogenous fatty acid amide with neuroprotective and anti‐
inflammatory actions. We performed a randomized, double‐blind, placebo‐controlled …

Allopregnanolone and its equipotent stereoisomer, pregnanolone (together termed ALLO),
are neuroactive steroids that positively and allosterically modulate the action of gamma …