Genome-wide association studies (GWAS) show conceptual promise to identify novel
mechanisms of major depressive disorder (MDD), but have not yet achieved this potential …

In the present study, three bi-3-azaoxoisoaporphine derivatives were synthesized and
intracerebroventricularly administrated to BALB/c mice. The antidepressant actions in stroke …

Aggressiveness and impulsivity are behaviors often comorbid with a variety of mood and
other psychiatric disorders and are predictors of suicide risk behavior. Stress exposure …

Abstract DHIPC (2, 4-dichloro-2-hydroxyl-4, 6-diisoprenyloxychalcone) is a new chalcone
compound. In this study, its antidepressant-like activity of compound DHIPC was evaluated …

In multiple sclerosis (MS) there is a disturbed balance between overactivated inflammatory
factors and inflammation-resolving and-inhibiting factors. The body can synthesize a series …

Background: Upregulation of the major catabolic enzyme for anandamide, fatty acid amide
hydrolase (FAAH), has been implicated in animal models of anxiety disorders, however no …

Depression is a chronic and debilitating psychiatric disorder that affects 300 million people
worldwide. Pharmacotherapy is one of the treatments. Due to delay in initiating treatment …

Rationale Mycobacterium vaccae (NCTC 11659) is an environmental saprophytic bacterium
with anti-inflammatory, immunoregulatory, and stress resilience properties. Previous studies …