Healthy aging and human longevity are intricate phenotypes affected by environmental
factors such as physical exercise, diet, health habits, and psychosocial situations as well as …

Discriminating the contribution of unmodifiable random intrinsic DNA replication errors ('bad
luck') to cancer development from those of other factors is critical for understanding cancer in …

Chronic inflammation, which is called “inflamm-aging”, is characterized by an increased
level of inflammatory cytokines in response to physiological and environmental stressors …

Nonalcoholic fatty liver disease (NAFLD) is the most common cause of liver dysfunction in
the Western world and is increasing owing to its close association with obesity and insulin …

Aging is the largest risk factor for most chronic diseases, which account for the majority of
morbidity and health care expenditures in developed nations. New findings suggest that …

Oxidative stress (OS), an imbalance between free radical generation and antioxidant
defence, is recognized as a key factor in the pathogenesis of adverse pregnancy outcomes …

Biological aging is characterized by a chronic low-grade inflammation level. This chronic
phenomenon has been named “inflamm-aging” and is a highly significant risk factor for …

The placenta is essential for the efficient delivery of nutrients and oxygen from mother to
fetus to maintain normal fetal growth. Dysfunctional placental development underpins many …

In response to persistent DNA damage, induction into cell senescence promotes an
immunogenic program which facilitates immune clearance of these damaged cells. Under …

Cellular senescence, a permanent state of cell cycle arrest accompanied by a complex
phenotype, is an essential mechanism that limits tumorigenesis and tissue damage. In …